头颈部鳞状细胞癌纳武单抗反应影响因素数据集

数据集获取（Figshare）

• 源站标题：DataSheet_1_Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma.docx
• DOI：10.3389/fimmu.2024.1390873.s001
• 发布日期：2024-07-29
• 文件数：1 个
• 文件总体积：600.38 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_1_Clinical_genomic_and_immune_microenvironmental_determinants_of_nivolumab_response_in_head_and_neck_squamous_cell_carcinoma_docx/26392024

命令行下载

curl -L -o "DataSheet_1_Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma.docx" "https://ndownloader.figshare.com/files/47986141"

文件清单

• DataSheet_1_Clinical, genomic and immune microenvironmental determinants of nivolumab response in head and neck squamous cell carcinoma.docx（600.38 KB）

文件总体积 600.38 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

BackgroundIn view of improving biomarkers predicting the efficacy of immunotherapy for head and neck squamous cell carcinoma (R/M HNSCC), this multicenter retrospective study aimed to identify clinical, tumor microenvironmental, and genomic factors that are related to therapeutic response to the anti- Programmed cell death protein 1 (PD-1) antibody, nivolumab, in patients with R/M HNSCC.
MethodsThe study compared 53 responders and 47 non-responders, analyzing formalin-fixed paraffin-embedded samples using 14-marker multiplex immunohistochemistry and targeted gene sequencing.
ResultsOf 100 patients included, responders had significantly lower smoking and alcohol index, higher incidence of immune related adverse events, and higher PD-1 ligand (PD-L1) expression in immune cells as well as PD-L1 combined positive score (CPS) than non-responders. The frequency of natural killer cells was associated with nivolumab response in patients with prior cetuximab use, but not in cetuximab-naïve status. Age-stratified analysis showed nivolumab response was linked to high CPS and lymphoid-inflamed profiles in patients aged ≥ 65. In contrast, lower NLR in peripheral blood counts was associated with response in patients aged Nivolumab treatment efficacy in HNSCC is influenced by a combination of clinical factors, age, prior treatment, immune environmental characteristics, and gene mutation profiles.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fimmu.2024.1390873.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_1_Clinical_genomic_and_immune_microenvironmental_determinants_of_nivolumab_response_in_head_and_neck_squamous_cell_carcinoma_docx/26392024）。