EWSR1-NFATc2融合阳性肉瘤多尺度组学评估数据记录

数据集获取（Figshare）

• 源站标题：Data record for the article: Multiscale -omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target
• DOI：10.6084/m9.figshare.14270366
• 发布日期：2021-04-22
• 文件数：1 个
• 文件总体积：55.58 KB
• 源站页面：https://springernature.figshare.com/articles/dataset/Data_record_for_the_article_Multiscale_-omic_assessment_of_EWSR1-NFATc2_fusion_positive_sarcomas_identifies_the_mTOR_pathway_as_a_potential_therapeutic_target/14270366

命令行下载

curl -L -o "Variants observed in EWSR1-NFATc2 sarcoma.xlsx" "https://ndownloader.figshare.com/files/27069569"

文件清单

• Variants observed in EWSR1-NFATc2 sarcoma.xlsx（55.58 KB）

文件总体积 55.58 KB（源站 API 实测）。

数据说明

This record provides details of the data supporting the claims of the related article: “Multiscale -omic assessment of EWSR1-NFATc2 fusion positive sarcomas identifies the mTOR pathway as a potential therapeutic target”.
The related study aimed to generate genomic profiles of EWSR1 fusion positive sarcomas to support the use of precision medicine in the development of therapeutics for the Ewing family of tumors.

Type of data: Genomic profiling data; Gene expression data; Drug sensitivity data; TCGA datasets, copy number data; case report data
Subject of data: EWSR1 fusion positive sarcoma patients
Sample size: 1,024 retrospectively analysed samples, 1 case report

Data access
The genomic profiling of pathogenic variants in EWSR1-NFATc2 fusion positive sarcomas are openly available as part of this figshare metadata record in the file ‘Variants observed in EWSR1-NFATc2 sarcoma.xlsx’.

The gene expression data used in this study are openly available from the Gene Expression Omnibus repository via the following accessions: https://identifiers.org/geo:GSE60740 and https://identifiers.org/geo:GSE34620.

The drug sensitivity data files used in this study were Cell_Lines_Details.xlsx; GDSC1_fitted_dose_response_17Jul19.xlsx; GDSC2_fitted_dose_response_17Jul19.xlsx; mutations_latest.csv; gene_cnv_2019-04-15_1109.csv; rnaseq_latest.csv. All of these files are openly accessible from the Genomics of Drug Sensitivity in Cancer Database (https://www.cancerrxgene.org/).

The TCGA dataset files used in this study were the Clinical merged and illuminahiseq_rnaseqv2-RSEM_genes_normalized files for each of the 33 cancer types. All of these files are openly accessible from firebrowse.org (http://gdac.broadinstitute.org/runs/stddata__2016_01_28/data/).

The copy number data files for each of the 33 cancer types were downloaded from cBioPortal (https://www.cbioportal.org/).

The case report data cannot be openly shared in order to protect patient confidentiality De-identified information is available in the text and supplemental figures of the related article. Clinical and genomic data for this case can be made available on request.

Corresponding author for this study
Jame

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.14270366（source: https://springernature.figshare.com/articles/dataset/Data_record_for_the_article_Multiscale_-omic_assessment_of_EWSR1-NFATc2_fusion_positive_sarcomas_identifies_the_mTOR_pathway_as_a_potential_therapeutic_target/14270366）。