哈萨克斯坦食管鳞状细胞癌患者转录组谱与分析（Table1）

数据集获取（Figshare）

• 源站标题：Table1_Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan.XLSX
• DOI：10.3389/fgene.2024.1249751.s001
• 发布日期：2024-03-18
• 文件数：1 个
• 文件总体积：1.84 MB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table1_Transcriptome_profiling_and_analysis_of_patients_with_esophageal_squamous_cell_carcinoma_from_Kazakhstan_XLSX/25426360

命令行下载

curl -L -o "Table1_Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan.XLSX" "https://ndownloader.figshare.com/files/45100516"

文件清单

• Table1_Transcriptome profiling and analysis of patients with esophageal squamous cell carcinoma from Kazakhstan.XLSX（1.84 MB）

文件总体积 1.84 MB（源站 API 实测）。

数据说明

Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal cancer in Central Asia, often diagnosed at advanced stages. Understanding population-specific patterns of ESCC is crucial for tailored treatments. This study aimed to unravel ESCC’s genetic basis in Kazakhstani patients and identify potential biomarkers for early diagnosis and targeted therapies. ESCC patients from Kazakhstan were studied. We analyzed histological subtypes and conducted in-depth transcriptome sequencing. Differential gene expression analysis was performed, and significantly dysregulated pathways were identified using KEGG pathway analysis (p-value < 0.05). Protein-protein interaction networks were constructed to elucidate key modules and their functions. Among Kazakhstani patients, ESCC with moderate dysplasia was the most prevalent subtype. We identified 42 significantly upregulated and two significantly downregulated KEGG pathways, highlighting molecular mechanisms driving ESCC pathogenesis. Immune-related pathways, such as viral protein interaction with cytokines, rheumatoid arthritis, and oxidative phosphorylation, were elevated, suggesting immune system involvement. Conversely, downregulated pathways were associated with extracellular matrix degradation, crucial in cancer invasion and metastasis. Protein-protein interaction network analysis revealed four distinct modules with specific functions, implicating pathways in esophageal cancer development. High-throughput transcriptome sequencing elucidated critical molecular pathways underlying esophageal carcinogenesis in Kazakhstani patients. Insights into dysregulated pathways offer potential for early diagnosis and precision treatment strategies for ESCC. Understanding population-specific patterns is essential for personalized approaches to ESCC management.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fgene.2024.1249751.s001（source: https://frontiersin.figshare.com/articles/dataset/Table1_Transcriptome_profiling_and_analysis_of_patients_with_esophageal_squamous_cell_carcinoma_from_Kazakhstan_XLSX/25426360）。