DIPG4423 同源原位 DMG 小鼠模型网络

资源简介

DIPG4423 同源原位 DMG 小鼠模型网络

DIPG4423 syngeneic orthotopic DMG murine model networks

该数据集来自 figshare，包含两个小鼠弥漫性中线胶质瘤（DMG）单细胞调控网络，分别对应脑干肿瘤样本 #1 和 #2。研究者考虑到调控网络可能具有物种特异性，采用 ARACNe-AP 标准流程对恶性细胞的归一化基因表达数据构建网络，每个样本一个网络。数据集共 2 个文件，样例为 DMG2_unPruned.rds 和 DMG1_unPruned.rds，作者为 Ester Calvo Fernandez，发布于 2025-08-26。该数据可用于研究 DMG 的调控网络、单细胞转录组分析及系统生物学相关探索（来源 figshare，CC BY 4.0 许可）。

【数据集背景】

项目资助方：This research was primarily funded by grants from Swim Across America and The Team Jack Foundation to J.P., as well as a Hyundai Hope on Wheels Impact Award to S.Z. and J.P., and the Gary and Yael Fegel Family Foundation. Additional funding support was provided by the Columbia University Irving Medical Center Herbert and Florence Irving Basic Science Scholar award and Pediatric Oncology Novel Research Fund Award awarded to J.P., as well as the Vagelos College of Physicians and Surgeons Interdisciplinary Research Initiatives Seed (IRIS) Fund. Further support was provided through the Postgraduate studies in North America and the Asia-Pacific region Fellowship by “La Caixa Foundation” and the Trainee Associate Member (TAM) predoctoral award from the Herbert Irving Comprehensive Cancer and Education Coordination centers at Columbia University, both awarded to E.C.F. T.T. was supported by fellowships from the German Research Foundation and ChadTough Defeat DIPG Foundation. R.D.G. was supported by the Hyundai Hope on Wheels Hope Scholar Award, Swim Across America, Rally Foundation, StacheStrong and the Musella Foundation. C-C.W. was supported by the Sebastian Strong Foundation, Swim Across America, the St. Baldrick’s Foundation Scholar Award, and the Pediatric Cancer Foundation. M.G. was partially supported by an ASCO Young Investigator Award as well as a grant from the Radiological Society of North America (RSNA). A.T.G. was supported, in part, by the Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (5T32GM007367-43), and in part by the NCI Ruth L. Kirschstein National Research Service Award Individual Fellowship (F30CA257765).

This work was further supported by the NCI Outstanding Investigator award R35 CA 197745, the NIH Shared Instrumentation Grants S10 OD012351 and S10 OD021764, and U01CA272610 (all to A.C.) and the NINDS Research Program Award R35 NS122339 (to R.W.-R). Additional grants included the NIH grant #。源站首次发布：2025-08-26。

【数据内容】

源站描述（机器翻译，仅供参考）：鉴于调控网络可能具有物种特异性，我们通过标准应用 ARACNe-AP 对来自脑干肿瘤 #1 和 #2 的恶性细胞的归一化基因表达数据生成了两个小鼠 DMG 单细胞网络（每个样本一个网络）。

【数据结构与技术规格】

文件数 2 个，合计 19.44 MB。数据集 DOI：10.6084/m9.figshare.29988508.v1。

【主题与分类】

源站学科分类：Translational and applied bioinformatics、Genomics and transcriptomics、Biological network analysis、Statistical and quantitative genetics。主题标签：Regulatory network、Pediatric brain tumors、single-cell RNA-sequencing (scRNAseq)、Systems biology。本站分类：肿瘤/弥漫性中线胶质瘤（DMG）。

【适用方向】

源站学科分类标注为 Translational and applied bioinformatics、Genomics and transcriptomics、Biological network analysis、Statistical and quantitative genetics。

【获取与许可】

源站页面：https://figshare.com/articles/dataset/DIPG4423_syngeneic_orthotopic_DMG_murine_model_networks/29988508

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Calvo Fernandez, Ester (2025). DIPG4423 syngeneic orthotopic DMG murine model networks. figshare. Dataset