队列样本特征数据集

数据集获取（Figshare）

• 源站标题：Sample characteristics of cohorts.
• DOI：10.1371/journal.pcbi.1013349.s005
• 发布日期：2025-08-06
• 文件数：1 个
• 文件总体积：19.23 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Sample_characteristics_of_cohorts_/29847118

命令行下载

curl -L -o "pcbi.1013349.s005.xlsx" "https://ndownloader.figshare.com/files/56974510"

文件清单

• pcbi.1013349.s005.xlsx（19.23 KB）

文件总体积 19.23 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Discovery of cancer driver pathways is essential for targeted therapies, since these pathways govern tumor progression and treatment resistance. However, their context-specific patterns across populations remain poorly understood. Leveraging pan-cancer genomic data, we apply our two models, EntCDP and ModSDP, to perform stratified analyses from four perspectives: region, tumor type, age group, and risk factors. Our results reveal the regional biases in perturbed pathways, such as PI3K-Akt in Chinese patients and GPCR in American patients with bladder cancer. Subtype comparisons highlight the mTOR signaling in lung adenocarcinoma and the FoxO signaling in lung squamous cell carcinoma. Pediatric-adult comparisons emphasize the enrichment of Ras signaling in pediatric acute myeloid leukemia and PAK signaling in pediatric glioblastoma, respectively. Risk factor associations further link Notch-mediated pathways to alcohol consumption and CDKN-regulated pathways to obesity-related cancers. Our findings demonstrate the utility of stratified driver pathway analysis in uncovering common and specific mechanisms, which can help prioritize context-aware therapeutic targets.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pcbi.1013349.s005（source: https://plos.figshare.com/articles/dataset/Sample_characteristics_of_cohorts_/29847118）。