早期(pN0)乳腺癌中基因组分级与组织学增殖标志物的预后价值

数据集获取（Figshare）

• 源站标题：Respective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma
• DOI：10.1371/journal.pone.0035184
• 发布日期：2012-04-18
• 文件数：2 个
• 文件总体积：9.36 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Respective_Prognostic_Value_of_Genomic_Grade_and_Histological_Proliferation_Markers_in_Early_Stage_pN0_Breast_Carcinoma/126172

命令行下载

curl -L -o "Figure_S1.tif" "https://ndownloader.figshare.com/files/334949"
curl -L -o "Figure_S2.tif" "https://ndownloader.figshare.com/files/335000"

文件清单

• Figure_S1.tif（3.12 MB）
• Figure_S2.tif（6.24 MB）

文件总体积 9.36 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Genomic grade (GG) is a 97-gene signature which improves the accuracy and prognostic value of histological grade (HG) in invasive breast carcinoma. Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score.
Methods
A series of 163 consecutive breast cancers was retained (pT1–2, pN0, pM0, 10-yr follow-up). GG was computed using MapQuant Dx®.
Results
GG was low (GG-1) in 48%, high (GG-3) in 31% and equivocal in 21% of cases. For HG-2 tumors, 50% were classified as GG-1, 18% as GG-3 whereas 31% remained equivocal. In a subgroup of 132 ER+/HER2− tumors GG was the most significant prognostic factor in multivariate Cox regression analysis adjusted for age and tumor size (HR = 5.23, p = 0.02).
Conclusions
In a reference comprehensive cancer center setting, compared to histological grade, GG added significant information on cell proliferation in breast cancers. In patients with HG-2 carcinoma, applying the GG to guide the treatment scheme could lead to a reduction in adjuvant therapy prescription. However, based on the results observed and considering (i) the relatively close prognostic values of GG and Ki67, (ii) the reclassification of about 30% of HG-2 tumors as Equivocal GG and (iii) the economical and technical requirements of the MapQuant micro-array GG test, the availability in the near future of a PCR-based Genomic Grade test with improved performances may lead to an introduction in clinical routine of this test for histological grade 2, ER positive, HER2 negative breast carcinoma.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0035184（source: https://plos.figshare.com/articles/dataset/Respective_Prognostic_Value_of_Genomic_Grade_and_Histological_Proliferation_Markers_in_Early_Stage_pN0_Breast_Carcinoma/126172）。