中国人群错配修复缺陷尿路上皮癌真实世界研究数据集

数据集获取（Figshare）

• 源站标题：Table_1_Clinicopathological characteristics, molecular landscape, and biomarker landscape for predicting the efficacy of PD-1/PD-L1 inhibitors in Chinese population with mismatch repair deficient urothelial carcinoma: a real-world study.docx
• DOI：10.3389/fimmu.2023.1269097.s003
• 发布日期：2023-11-06
• 文件数：1 个
• 文件总体积：18.20 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_Clinicopathological_characteristics_molecular_landscape_and_biomarker_landscape_for_predicting_the_efficacy_of_PD-1_PD-L1_inhibitors_in_Chinese_population_with_mismatch_repair_deficient_urothelial_carcinoma_a_real-world_study_docx/24502945

命令行下载

curl -L -o "Table_1_Clinicopathological characteristics, molecular landscape, and biomarker landscape for predicting the efficacy of PD-1/PD-L1 inhibitors in Chin.docx" "https://ndownloader.figshare.com/files/43046920"

文件清单

• Table_1_Clinicopathological characteristics, molecular landscape, and biomarker landscape for predicting the efficacy of PD-1/PD-L1 inhibitors in Chin.docx（18.20 KB）

文件总体积 18.20 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Urothelial carcinoma (UC) with deficient mismatch repair (dMMR) is a specific subtype of UC characterized by the loss of mismatch repair (MMR) proteins and its association with Lynch syndrome (LS). However, comprehensive real-world data on the incidence, clinicopathological characteristics, molecular landscape, and biomarker landscape for predicting the efficacy of PD-1/PD-L1 inhibitors in the Chinese patients with dMMR UC remains unknown. We analyzed 374 patients with bladder urothelial carcinoma (BUC) and 232 patients with upper tract urothelial carcinoma (UTUC) using tissue microarrays, immunohistochemistry, and targeted next-generation sequencing. Results showed the incidence of dMMR UC was higher in the upper urinary tract than in the bladder. Genomic analysis identified frequent mutations in KMT2D and KMT2C genes and LS was confirmed in 53.8% of dMMR UC cases. dMMR UC cases displayed microsatellite instability-high (MSI-H) (PCR method) in 91.7% and tumor mutational burden-high (TMB-H) in 40% of cases. The density of intratumoral CD8+ T cells correlated with better overall survival in dMMR UC patients. Positive PD-L1 expression was found in 20% cases, but some patients positively responded to immunotherapy despite negative PD-L1 expression. Our findings provide valuable insights into the characteristics of dMMR UC in the Chinese population and highlights the relevance of genetic testing and immunotherapy biomarkers for treatment decisions.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fimmu.2023.1269097.s003（source: https://frontiersin.figshare.com/articles/dataset/Table_1_Clinicopathological_characteristics_molecular_landscape_and_biomarker_landscape_for_predicting_the_efficacy_of_PD-1_PD-L1_inhibitors_in_Chinese_population_with_mismatch_repair_deficient_urothelial_carcinoma_a_real-world_study_docx/24502945）。