NPM-ALK信号网络敏感性分析揭示间变性大细胞淋巴瘤联合治疗的重要通路

资源简介

NPM-ALK信号网络敏感性分析揭示间变性大细胞淋巴瘤联合治疗的重要通路

【数据集背景】

本数据集源站标题为《Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy》。配套论文《Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy》发表于 PLOS ONE（2016），DOI：10.1371/journal.pone.0163011。源站首次发布：2016-09-26。

【数据内容】

源站原始描述：A large subset of anaplastic large cell lymphoma (ALCL) patients harbour a somatic aberration in which anaplastic lymphoma kinase (ALK) is fused to nucleophosmin (NPM) resulting in a constitutively active signalling fusion protein, NPM-ALK. We computationally simulated the signalling network which mediates pathological cell survival and proliferation through NPM-ALK to identify therapeutically targetable nodes through which it may be possible to regain control of the tumourigenic process. The si…

【数据结构与技术规格】

文件数 2 个，合计 3.64 MB。S1 Table.PDF：application/pdf，38.21 KB。S1 Fig.TIFF：image/tiff，3.60 MB。数据集 DOI：10.1371/journal.pone.0163011。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Cell Biology、Genetics、Molecular Biology、Biotechnology。主题标签：tumourigenic、JAK、VAV、Cell Lymphoma Combination Therapy、protein tyrosine phosphatase、STAT、NPM-ALK Signalling Network、SHP、proliferation、importance。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Cell Biology、Genetics、Molecular Biology、Biotechnology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Sensitivity_Analysis_of_the_NPM-ALK_Signalling_Network_Reveals_Important_Pathways_for_Anaplastic_Large_Cell_Lymphoma_Combination_Therapy/3861996

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Buetti-Dinh, Antoine; O’Hare, Thomas; Friedman, Ran (2016). Sensitivity Analysis of the NPM-ALK Signalling Network Reveals Important Pathways for Anaplastic Large Cell Lymphoma Combination Therapy. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。