大颗粒淋巴细胞白血病细胞系模型中IFN-γ-STAT1信号通路的失调

资源简介

大颗粒淋巴细胞白血病细胞系模型中IFN-γ-STAT1信号通路的失调

【数据集背景】

本数据集源站标题为《Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia》。配套论文《Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia》发表于 PLOS ONE（2018），DOI：10.1371/journal.pone.0193429。源站首次发布：2018-02-23。

【数据内容】

源站原始描述：T cell large granular lymphocyte leukemia (T-LGLL) is a rare incurable disease that is characterized by defective apoptosis of cytotoxic CD8+ T cells. Chronic activation of the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway is a hallmark of T-LGLL. One manifestation is the constitutive phosphorylation of tyrosine 701 of STAT1 (p-STAT1). T-LGLL patients also exhibit elevated serum levels of the STAT1 activator, interferon-γ (IFN-γ), thus contributing to an inflam…

【数据结构与技术规格】

文件数 3 个，合计 239.12 KB。S1 Fig.tif：image/tiff，90.57 KB。S2 Fig.tif：image/tiff，77.17 KB。S3 Fig.tif：image/tiff，71.38 KB。数据集 DOI：10.1371/journal.pone.0193429。

【主题与分类】

源站学科分类：Microbiology、Cell Biology、Genetics、Molecular Biology、Immunology、Cancer。主题标签：STAT 1、STAT 1 activation、JAK、cell line model、IFN、T-LGLL、STAT 5b proteins、JAK-STAT、p-STAT 1、IL。

【适用方向】

源站学科分类标注为 Microbiology、Cell Biology、Genetics、Molecular Biology、Immunology、Cancer。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Dysregulation_of_the_IFN-_-STAT1_signaling_pathway_in_a_cell_line_model_of_large_granular_lymphocyte_leukemia/5922382

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Kulling, Paige M.; Olson, Kristine C.; Hamele, Cait E.; Toro, Mariella F.; Tan, Su-Fern; J. Feith, David; et al. (2018). Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。