化学诱导间变性淋巴瘤激酶（ALK）降解数据集

资源简介

化学诱导间变性淋巴瘤激酶（ALK）降解数据集

【数据集背景】

本数据集源站标题为《Chemically Induced

Degradation of Anaplastic Lymphoma

Kinase (ALK)》。配套论文《Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)》发表于 Journal of Medicinal Chemistry（2018），DOI：10.1021/acs.jmedchem.7b01655。源站首次发布：2018-04-16。

【数据内容】

源站原始描述：We present the development of the first small molecule degraders that can induce anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines. These degraders were developed through conjugation of known pyrimidine-based ALK inhibitors, TAE684 or LDK378, and the cereblon ligand pomalidomide. We demonstrate that in some cell types degrader potency is compromised by expression of drug transpor…

主表 jm7b01655_si_001.csv 含 261 列、样本前 1 行结构完整。

【数据结构与技术规格】

文件数 1 个，合计 2.25 KB。jm7b01655_si_001.csv：text/plain，2.25 KB。数据集 DOI：10.1021/acs.jmedchem.7b01655.s001。

【主题与分类】

源站学科分类：Biophysics、Biochemistry、Space Science、Medicine、Microbiology、Cell Biology。主题标签：ALCL、Chemically Induced Degradation、molecule degraders、non-small-cell lung cancer、drug transporter ABCB 1.、FAK、cereblon ligand pomalidomide、pyrimidine-based ALK inhibitors、NB、anaplastic lymphoma kinase。

【适用方向】

结构化表格数据可直接用于统计建模、特征工程与队列分析。源站学科分类标注为 Biophysics、Biochemistry、Space Science、Medicine、Microbiology、Cell Biology。

【获取与许可】

源站页面：https://acs.figshare.com/articles/dataset/Chemically_Induced_Degradation_of_Anaplastic_Lymphoma_Kinase_ALK_/6178964

使用许可：CC BY-NC 4.0（https://creativecommons.org/licenses/by-nc/4.0/）。

规范引用：Powell, Chelsea E.; Gao, Yang; Tan, Li; Donovan, Katherine A.; Nowak, Radosław P.; Loehr, Amanda; et al. (2018). Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). ACS Publications. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。