The Acinetobacter trimeric autotransporter adhesin Ata controls key virulence traits of Acinetobacter baumannii

数据集获取（Figshare）

• 源站标题：The <i>Acinetobacter</i> trimeric autotransporter adhesin Ata controls key virulence traits of <i>Acinetobacter baumannii</i>
• DOI：10.6084/m9.figshare.7583699.v2
• 发布日期：2019-12-24
• 文件数：7 个
• 文件总体积：4.57 MB
• 源站页面：https://tandf.figshare.com/articles/dataset/The_i_Acinetobacter_i_trimeric_autotransporter_adhesin_Ata_controls_key_virulence_traits_of_i_Acinetobacter_baumannii_i_/7583699

命令行下载

curl -L -o "Supplement_Figure 1_.pptx" "https://ndownloader.figshare.com/files/14083106"
curl -L -o "Supplement_Figure 2.pptx" "https://ndownloader.figshare.com/files/14083109"
curl -L -o "Supplement_Figure 3.pptx" "https://ndownloader.figshare.com/files/14083112"
curl -L -o "Supplement_Figure 4.pptx" "https://ndownloader.figshare.com/files/14083115"
curl -L -o "Supplement_Figure 5.pptx" "https://ndownloader.figshare.com/files/14083118"
curl -L -o "Weidensdorfer_Supplement Methods_.docx" "https://ndownloader.figshare.com/files/14083121"
curl -L -o "Weidensdorfer_Supplement Tables_.docx" "https://ndownloader.figshare.com/files/14083124"

文件清单

• Supplement_Figure 1_.pptx（49.37 KB）
• Supplement_Figure 2.pptx（82.54 KB）
• Supplement_Figure 3.pptx（251.65 KB）
• Supplement_Figure 4.pptx（480.69 KB）
• Supplement_Figure 5.pptx（3.60 MB）
• Weidensdorfer_Supplement Methods_.docx（59.09 KB）
• Weidensdorfer_Supplement Tables_.docx（41.08 KB）

文件总体积 4.57 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Acinetobacter baumannii is a Gram-negative pathogen that causes a multitude of nosocomial infections. The Acinetobacter trimeric autotransporter adhesin (Ata) belongs to the superfamily of trimeric autotransporter adhesins which are important virulence factors in many Gram-negative species. Phylogenetic profiling revealed that ata is present in 78% of all sequenced A. baumannii isolates but only in 2% of the closely related species A. calcoaceticus and A. pittii. Employing a markerless ata deletion mutant of A. baumannii ATCC 19606 we show that adhesion to and invasion into human endothelial and epithelial cells depend on Ata. Infection of primary human umbilical cord vein endothelial cells (HUVECs) with A. baumannii led to the secretion of interleukin (IL)-6 and IL-8 in a time- and Ata-dependent manner. Furthermore, infection of HUVECs by WT A. baumannii was associated with higher rates of apoptosis via activation of caspases-3 and caspase-7, but not necrosis, in comparison to ∆ata. Ata deletion mutants were furthermore attenuated in their ability to kill larvae of Galleria mellonella and to survive in larvae when injected at sublethal doses. This indicates that Ata is an important multifunctional virulence factor in A. baumannii that mediates adhesion and invasion, induces apoptosis and contributes to pathogenicity in vivo.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.7583699.v2（source: https://tandf.figshare.com/articles/dataset/The_i_Acinetobacter_i_trimeric_autotransporter_adhesin_Ata_controls_key_virulence_traits_of_i_Acinetobacter_baumannii_i_/7583699）。