光不敏感银(I)氰肟配合物作为留置医疗器械抗菌剂

数据集获取（Figshare）

• 源站标题：Light Insensitive Silver(I) Cyanoximates As Antimicrobial Agents for Indwelling Medical Devices
• DOI：10.1021/ic100830x.s001
• 发布日期：2010-11-01
• 文件数：1 个
• 文件总体积：13.60 KB
• 源站页面：https://acs.figshare.com/articles/dataset/Light_Insensitive_Silver_I_Cyanoximates_As_Antimicrobial_Agents_for_Indwelling_Medical_Devices/2718286

命令行下载

curl -L -o "ic100830x_si_001.cif" "https://ndownloader.figshare.com/files/4394236"

文件清单

• ic100830x_si_001.cif（13.60 KB）

文件总体积 13.60 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Ten silver(I) cyanoximates of AgL composition (L = NC-C(NO)-R, where R is electron withdrawing groups: -CN, -C(O)NR2, -C(O)R′ (alkyl), -C(O)OEt, 2-heteroaryl fragments such as 2-pyridyl, 2-benzimidazolyl, 2-benzoxazolyl, 2-benzthiazolyl) were synthesized and characterized using spectroscopic methods and X-ray analysis. Crystal structures of four complexes were determined and revealed the formation of two-dimensional (2D) coordination polymers of different complexity in which anions exhibit bridging or combined chelate and bridging binding modes. In these compounds, anions are in the nitroso form. All studied AgL complexes are sparingly soluble in water and are thermally stable to 150 °C. Synthesized compounds demonstrated remarkable insensitivity toward visible light and UV-radiation, which was explained based on their polymeric structures with multiple covalent bonds between bridging cyanoxime ligands and Ag(I) centers. All 10 silver(I) cyanoximates were tested in vitro on the subject of their antimicrobial activity against both Gram-positive and Gram-negative microorganisms such as Escherichia coli, Klebsiella pneumoniae, Proteus sp., Pseudomonas aeruginosa, Enterococcus hirae, Streptococcus mutans, Staphylococcus aureus, and Mycobacterium fortuitum as well as against Candida albicans in solutions, and in the solid state as pressed pellets and dried filter paper disks presoaked with solutions of AgL in DMF. Results showed pronounced antimicrobial activity for all investigated complexes. A combination of five factors: (1) light insensitivity, (2) poor water solubility, (3) high thermal stability, (4) lack of toxicity of organic ligands, and (5) in vitro antimicrobial activity allows development of silver(I) cyanoximates for medical applications. These include antimicrobial additives to acrylate glue, cured by UV-radiation, used in introduction of prosthetic joints and dental implants, and prevention of biofilm formation on several types of indwelling medical devices.

许可

CC BY-NC 4.0

引用

学术使用请引用 DOI 10.1021/ic100830x.s001（source: https://acs.figshare.com/articles/dataset/Light_Insensitive_Silver_I_Cyanoximates_As_Antimicrobial_Agents_for_Indwelling_Medical_Devices/2718286）。