G6PD杂合子女性伯氨喹治疗间日疟溶血嵌套队列数据集

数据集获取（Figshare）

• 源站标题：Haemolysis in G6PD Heterozygous Females Treated with Primaquine for <i>Plasmodium vivax</i> Malaria: A Nested Cohort in a Trial of Radical Curative Regimens
• DOI：10.1371/journal.pmed.1002224
• 发布日期：2017-02-07
• 文件数：6 个
• 文件总体积：1.54 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Haemolysis_in_G6PD_Heterozygous_Females_Treated_with_Primaquine_for_i_Plasmodium_vivax_i_Malaria_A_Nested_Cohort_in_a_Trial_of_Radical_Curative_Regimens/4626508

命令行下载

curl -L -o "pmed.1002224.s001.pdf" "https://ndownloader.figshare.com/files/7528882"
curl -L -o "pmed.1002224.s002.pdf" "https://ndownloader.figshare.com/files/7528885"
curl -L -o "pmed.1002224.s003.xls" "https://ndownloader.figshare.com/files/7528888"
curl -L -o "pmed.1002224.s004.xls" "https://ndownloader.figshare.com/files/7528891"
curl -L -o "pmed.1002224.s005.pdf" "https://ndownloader.figshare.com/files/7528897"
curl -L -o "pmed.1002224.s006.pdf" "https://ndownloader.figshare.com/files/7528900"

文件清单

• pmed.1002224.s001.pdf（90.63 KB）
• pmed.1002224.s002.pdf（242.01 KB）
• pmed.1002224.s003.xls（923.14 KB）
• pmed.1002224.s004.xls（135.17 KB）
• pmed.1002224.s005.pdf（78.98 KB）
• pmed.1002224.s006.pdf（66.28 KB）

文件总体积 1.54 MB（源站 API 实测）。

数据说明

Background
Radical cure of Plasmodium vivax malaria with 8-aminoquinolines (primaquine or tafenoquine) is complicated by haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. G6PD heterozygous females, because of individual variation in the pattern of X-chromosome inactivation (Lyonisation) in erythroid cells, may have low G6PD activity in the majority of their erythrocytes, yet are usually reported as G6PD “normal” by current phenotypic screening tests. Their haemolytic risk when treated with 8-aminoquinolines has not been well characterized.
Methods and Findings
In a cohort study nested within a randomised clinical trial that compared different treatment regimens for P. vivax malaria, patients with a normal standard NADPH fluorescent spot test result (≳30%–40% of normal G6PD activity) were randomised to receive 3 d of chloroquine or dihydroartemisinin-piperaquine in combination with primaquine, either the standard high dose of 0.5 mg base/kg/day for 14 d or a higher dose of 1 mg base/kg/d for 7 d. Patterns of haemolysis were compared between G6PD wild-type and G6PD heterozygous female participants. Between 21 February 2012 and 04 July 2014, 241 female participants were enrolled, of whom 34 were heterozygous for the G6PD Mahidol variant. Haemolysis was substantially greater and a larger proportion of participants reached the threshold of clinically significant haemolysis (fractional haematocrit reduction >25%) in G6PD heterozygotes taking the higher (7 d) primaquine dose (9/17 [53%]) compared with G6PD heterozygotes taking the standard high (14 d) dose (2/16 [13%]; p = 0.022). In heterozygotes, the mean fractional haematocrit reductions were correspondingly greater with the higher primaquine dose (7-d regimen): −20.4% (95% CI −26.0% to −14.8%) (nadir on day 5) compared with the standard high (14 d) dose: −13.1% (95% CI −17.6% to −8.6%) (nadir day 6). Two heterozygotes taking the higher (7 d) primaquine dose required blood transfusion. In wild-type participants, mean haematocrit reductions were clinically insignificant and similar with both doses: −5.8 (95% CI −7.2% to −4.4%) (nadir day 3) compared with −5.5% (95% CI −7.4% to −3.7%)

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1002224（source: https://plos.figshare.com/articles/dataset/Haemolysis_in_G6PD_Heterozygous_Females_Treated_with_Primaquine_for_i_Plasmodium_vivax_i_Malaria_A_Nested_Cohort_in_a_Trial_of_Radical_Curative_Regimens/4626508）。