Uxt缺陷小鼠表现出视网膜色素变性样特征及异常自噬激活数据集

资源简介

Uxt缺陷小鼠表现出视网膜色素变性样特征及异常自噬激活数据集

【数据集背景】

本数据集源站标题为《Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation》。配套论文《Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation》发表于 Autophagy（2020），DOI：10.1080/15548627.2020.1796015。项目资助方：This work was supported by the National Natural Science Foundation of China [31601068]; National Natural Science Foundation of China [81672029]; National Natural Science Foundation of China [31730018]; “Double First-Class” Project of China Pharmaceutical University [CPU2018GF10]; Postgraduate Research & Practice Innovation Program of Jiangsu Province [3322000026]; Jiangsu Innovative and Entrepreneurial Talents Program, the National New Drug Innovation Major Project of China [2017ZX09309027]; National Key R&D Program of China [2016YFA0501800]; Open Project of State Key Laboratory of Natural Medicines [SKLNMZZCX201802]; “Double First-Class” Project of China Pharmaceutical University [CPU2018GF10]; Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD].。源站首次发布：2020-08-24。

【数据内容】

源站原始描述：UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, is widely expressed in diverse human and mouse tissues and is more abundant in retina and kidney. However, the functional characterization of UXT at tissue level was largely unknown. Here, we reported that mice deficient in UXT exhibited salient features of retinal degenerative disease, similar to retinitis pigmentosa. Conditional knockout (CKO) of Uxt led to retinal degeneration and pigmentation in mice retin…

【数据结构与技术规格】

文件数 5 个，合计 63.13 MB。FigS2.pdf：application/pdf，487.82 KB。FigS3.pdf：application/pdf，627.43 KB。数据集 DOI：10.6084/m9.figshare.12851417.v1。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Cell Biology、Genetics、Molecular Biology、Neuroscience。主题标签：Apoptosis、autophagy、degeneration、MTOR、photoreceptor、retinitis pigmentosa、UXT。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Cell Biology、Genetics、Molecular Biology、Neuroscience。

【获取与许可】

源站页面：https://tandf.figshare.com/articles/dataset/Mice_deficient_in_UXT_exhibit_retinitis_pigmentosa-like_features_via_aberrant_autophagy_activation/12851417

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. Taylor & Francis. Pan, Mingyu; Yin, Yue; Wang, Xinxia; Wang, Quanyi; Zhang, Lele; Hu, Haiyang; et al

【使用注意】

· 源站最后修改于 2024-02-15，引用时请注意版本时效。