巴德特-别德尔综合征蛋白质对胰岛素受体运输的调控

资源简介

巴德特-别德尔综合征蛋白质对胰岛素受体运输的调控

【数据集背景】

本数据集源站标题为《Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins》。配套论文《Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins》发表于 PLOS Genetics（2015），DOI：10.1371/journal.pgen.1005311。源站首次发布：2015-06-23。

【数据内容】

源站原始描述：Insulin and its receptor are critical for the regulation of metabolic functions, but the mechanisms underlying insulin receptor (IR) trafficking to the plasma membrane are not well understood. Here, we show that Bardet Biedl Syndrome (BBS) proteins are necessary for IR localization to the cell surface. We demonstrate that the IR interacts physically with BBS proteins, and reducing the expression of BBS proteins perturbs IR expression in the cell surface. We show the consequence of disrupting BBS…

【数据结构与技术规格】

文件数 5 个，合计 4.96 MB。S1_Fig.tif：image/tiff，266.99 KB。S2_Fig.tif：image/tiff，316.84 KB。S3_Fig.tif：image/tiff，2.61 MB。数据集 DOI：10.1371/journal.pgen.1005311。

【主题与分类】

源站学科分类：Uncategorised。主题标签：cell surface、IR cell surface expression、Bardet Biedl Syndrome、M 390R mutation、BBS proteins perturbs IR expression、BBS 1 gene、Bardet Biedl Syndrome Proteins Insulin、novel mechanism accounting、BBS proteins、Insulin Receptor Trafficking。

【适用方向】

源站学科分类标注为 Uncategorised。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Regulation_of_Insulin_Receptor_Trafficking_by_Bardet_Biedl_Syndrome_Proteins_/1461390

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：D. Starks, Rachel; M. Beyer, Andreas; Fu Guo, Deng; Boland, Lauren; Zhang, Qihong; C. Sheffield, Val; et al. (2016). Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-04，引用时请注意版本时效。