Snx10缺陷导致小鼠骨石化性佝偻病的研究数据集：源于破骨细胞活性障碍与胃酸依赖性钙吸收缺失

资源简介

Snx10缺陷导致小鼠骨石化性佝偻病的研究数据集：源于破骨细胞活性障碍与胃酸依赖性钙吸收缺失

【数据集背景】

本数据集源站标题为《Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption》。配套论文《Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption》发表于 PLOS Genetics（2015），DOI：10.1371/journal.pgen.1005057。源站首次发布：2015-03-26。

【数据内容】

源站原始描述：Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in which Snx10 was knocked down globally or knocked out in osteoclasts. Endocytosis is severely defective in Snx10-deficent osteoclasts, as is extracellular acidification, ruffled border formation, and bone resorption. We also discovered that Snx10 is h…

【数据结构与技术规格】

文件数 10 个，合计 12.93 MB。S1_Fig.tif：image/tiff，584.81 KB。S2_Fig.tif：image/tiff，4.10 MB。S3_Fig.tif：image/tiff，1.71 MB。数据集 DOI：10.1371/journal.pgen.1005057。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：Snx 10 mutation need、Snx 10 Deficiency、Failed Osteoclast Activity、body calcium balance、stomach pH、Snx 10。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Osteopetrorickets_due_to_Snx10_Deficiency_in_Mice_Results_from_Both_Failed_Osteoclast_Activity_and_Loss_of_Gastric_Acid_Dependent_Calcium_Absorption_/1357281

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Ye, Liang; R. Morse, Leslie; Zhang, Li; Sasaki, Hajime; C. Mills, Jason; R. Odgren, Paul; et al. (2016). Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-03，引用时请注意版本时效。