甲状腺功能减退最优激素替代疗法——模型预测控制方法的数据表

数据集获取（Figshare）

• 源站标题：DataSheet_1_Optimal Hormone Replacement Therapy in Hypothyroidism - A Model Predictive Control Approach.pdf
• DOI：10.3389/fendo.2022.884018.s001
• 发布日期：2022-06-24
• 文件数：1 个
• 文件总体积：1.58 MB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_1_Optimal_Hormone_Replacement_Therapy_in_Hypothyroidism_-_A_Model_Predictive_Control_Approach_pdf/20140703

命令行下载

curl -L -o "DataSheet_1_Optimal Hormone Replacement Therapy in Hypothyroidism - A Model Predictive Control Approach.pdf" "https://ndownloader.figshare.com/files/36020228"

文件清单

• DataSheet_1_Optimal Hormone Replacement Therapy in Hypothyroidism - A Model Predictive Control Approach.pdf（1.58 MB）

文件总体积 1.58 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

In this paper, we address the problem of optimal thyroid hormone replacement strategy development for hypothyroid patients. This is challenging for the following reasons. First, it is difficult to determine the correct dosage leading to normalized serum thyroid hormone concentrations of a patient. Second, it remains unclear whether a levothyroxine L-T4) monotherapy or a liothyronine/levothyroxine (L-T3/L-T4) combined therapy is more suitable to treat hypothyroidism. Third, the optimal intake frequency of L-T3/L-T4 is unclear. We address these issues by extending a mathematical model of the pituitary-thyroid feedback loop to be able to consider an oral intake of L-T3/L-T4. A model predictive controller (MPC) is employed to determine optimal dosages with respect to the thyroid hormone concentrations for each type of therapy. The results indicate that the L-T3/L-T4 combined therapy is slightly better (in terms of the achieved hormone concentrations) to treat hypothyroidism than the L-T4 monotherapy. In case of a specific genetic variant, namely genotype CC in polymorphism rs2235544 of gene DIO1, the simulation results suggest that the L-T4 monotherapy is better to treat hypothyroidism. In turn, when genotype AA is considered, the L-T3/L-T4 combined therapy is better to treat hypothyroidism. Furthermore, when genotype CC of polymorphism rs225014 (also referred to as c.274A>G or p.Thr92Ala) in the DIO2 gene is considered, the outcome of the L-T3/L-T4 combined therapy is better in terms of the steady-state hormone concentrations (for a triiodothyronine setpoint at the upper limit of the reference range of healthy individuals). Finally, the results suggest that two daily intakes of L-T3 could be the best trade-off between stable hormone concentrations and inconveniences for the patient.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fendo.2022.884018.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_1_Optimal_Hormone_Replacement_Therapy_in_Hypothyroidism_-_A_Model_Predictive_Control_Approach_pdf/20140703）。