通过X连锁垂体功能减退症小鼠模型揭示多聚丙氨酸扩展疾病的病理机制

资源简介

通过X连锁垂体功能减退症小鼠模型揭示多聚丙氨酸扩展疾病的病理机制

【数据集背景】

本数据集源站标题为《Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism》。配套论文《Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism》发表于 PLoS Genetics（2013），DOI：10.1371/journal.pgen.1003290。源站首次发布：2013-03-08。

【数据内容】

源站原始描述：Polyalanine expansions in transcription factors have been associated with eight distinct congenital human diseases. It is thought that in each case the polyalanine expansion causes misfolding of the protein that abrogates protein function. Misfolded proteins form aggregates when expressed in vitro; however, it is less clear whether aggregation is of relevance to these diseases in vivo. To investigate this issue, we used targeted mutagenesis of embryonic stem (ES) cells to generate mice with a po…

【数据结构与技术规格】

文件数 4 个，合计 11.88 MB。Figure_S1.tif：image/tiff，2.17 MB。Figure_S2.tif：image/tiff，3.66 MB。Figure_S3.tif：image/tiff，4.02 MB。数据集 DOI：10.1371/journal.pgen.1003290。

【主题与分类】

源站学科分类：Genetics、Developmental Biology。主题标签：mechanistic、pathology、polyalanine、disorders、revealed、linked、hypopituitarism。

【适用方向】

源站学科分类标注为 Genetics、Developmental Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Mechanistic_Insight_into_the_Pathology_of_Polyalanine_Expansion_Disorders_Revealed_by_a_Mouse_Model_for_X_Linked_Hypopituitarism__/647215

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Hughes, James; Piltz, Sandra; Rogers, Nicholas; McAninch, Dale; Rowley, Lynn; Thomas, Paul (2016). Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。