IL10RA缺陷克罗恩病患儿脐带血移植后植入失败的粪便微生物特征（数据表2）

数据集获取（Figshare）

• 源站标题：DataSheet_2_Fecal Microbial Signatures Are Associated With Engraftment Failure Following Umbilical Cord Blood Transplantation in Pediatric Crohn’s Disease Patients With IL10RA Deficiency.pdf
• DOI：10.3389/fphar.2020.580817.s002
• 发布日期：2020-10-08
• 文件数：1 个
• 文件总体积：1.65 MB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Fecal_Microbial_Signatures_Are_Associated_With_Engraftment_Failure_Following_Umbilical_Cord_Blood_Transplantation_in_Pediatric_Crohn_s_Disease_Patients_With_IL10RA_Deficiency_pdf/13067309

命令行下载

curl -L -o "DataSheet_2_Fecal Microbial Signatures Are Associated With Engraftment Failure Following Umbilical Cord Blood Transplantation in Pediatric Crohn’s Dis.pdf" "https://ndownloader.figshare.com/files/25001345"

文件清单

• DataSheet_2_Fecal Microbial Signatures Are Associated With Engraftment Failure Following Umbilical Cord Blood Transplantation in Pediatric Crohn’s Dis.pdf（1.65 MB）

文件总体积 1.65 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

ObjectivesUmbilical cord blood transplantation (UCBT) is associated with a relatively high rate of engraftment failure. This study aimed at exploring whether any fecal microbiota could be associated with engraftment failure following UCBT in Crohn’s disease patients with IL10RA deficiency.
MethodsThirteen patients were recruited and their 230 fecal samples were collected longitudinally from immediately before conditioning chemotherapy to 8 weeks post the UCBT. The V3-V4 regions of the bacterial 16S rRNA gene were amplified by PCR and sequenced, followed by bioinformatics analyses.
ResultsFollowing the UCBT, 7 out of 13 patients achieved neutrophil and platelet engraftment with a median of 21 and 28 days, respectively (S group), while 6 patients failed to achieve engraftment (F group). In comparison with that in the S group, significantly lower Shannon diversity values on the UCBT day (P = 0.0176) and less abundance of Bifidobacterium longum, Bifidobacterium pseudolongum, Enterobacteriaceae_538000, and one taxon of Lachnospiraceae family was detected in the F group, accompanied by significantly higher abundances of four taxa including Lautropia, Pseudomonas, and species Microvirgula aerodenitrificans during the chemotherapy period as well as UCBT. The abundances of thirty OTUs were correlated significantly with clinical indices.
ConclusionsMicrobial indicators of reduced diversity of microbiota and signatures of specific bacterial abundances, such as a lower abundance of Bifidobacterium longum, for engraftment failure would require validation. These indicators may help for the risk stratification in patients with IL10RA deficiency undergoing UCBT.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fphar.2020.580817.s002（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_2_Fecal_Microbial_Signatures_Are_Associated_With_Engraftment_Failure_Following_Umbilical_Cord_Blood_Transplantation_in_Pediatric_Crohn_s_Disease_Patients_With_IL10RA_Deficiency_pdf/13067309）。