Activation of complement factor B contributes to murine and human myocardial ischemia/reperfusion injury
This dataset investigates the role of complement factor B (fB) in myocardial ischemia/reperfusion injury using murine models and human clinical samples. It includes measurements of myocardial necrosis extent, fB protein activation levels, and deposition of C3 activation products in mouse models of regional myocardial ischemia/reperfusion, as well as correlation analyses between activated fB (Bb) levels in intracoronary blood samples and cardiac troponin I (a biomarker of myocardial necrosis) in humans undergoing cardiopulmonary bypass surgery. The data are derived from experimentally induced mouse models and clinical samples collected during cardiac surgery. The primary research focus is on the pathological mechanisms of the alternative complement pathway in myocardial ischemia/reperfusion injury, with applications in immunological studies of cardiovascular diseases and exploration of potential therapeutic targets.
基本信息
About
This dataset investigates the role of complement factor B (fB) in myocardial ischemia/reperfusion injury using murine models and human clinical samples. It includes measurements of myocardial necrosis extent, fB protein activation levels, and deposition of C3 activation products in mouse models of regional myocardial ischemia/reperfusion, as well as correlation analyses between activated fB (Bb) levels in intracoronary blood samples and cardiac troponin I (a biomarker of myocardial necrosis) in humans undergoing cardiopulmonary bypass surgery. The data are derived from experimentally induced mouse models and clinical samples collected during cardiac surgery. The primary research focus is on the pathological mechanisms of the alternative complement pathway in myocardial ischemia/reperfusion injury, with applications in immunological studies of cardiovascular diseases and exploration of potential therapeutic targets.
https://figshare.com/articles/dataset/Activation_of_complement_factor_B_contributes_to_murine_and_human_myocardial_ischemia_reperfusion_injury/5156749
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数据说明
该数据集通过小鼠模型和人类临床样本，研究了补体因子B（fB）在心肌缺血再灌注损伤中的作用。数据内容包括：小鼠心肌缺血再灌注实验中的组织坏死程度、fB蛋白激活水平、C3激活产物沉积的测量结果；人类心脏手术中冠状动脉血样内激活fB（Bb）水平与心肌坏死标志物（心肌肌钙蛋白I）的相关性分析。数据来源为实验诱导的小鼠模型和人类心脏手术中的临床样本，主要研究方向为补体替代途径在心肌缺血再灌注损伤中的病理机制，应用场景包括心血管疾病的免疫学研究和潜在治疗靶点探索。
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