小鼠内皮细胞Acvrl1缺失导致与Endoglin表达减少相关的动静脉畸形

资源简介

小鼠内皮细胞Acvrl1缺失导致与Endoglin表达减少相关的动静脉畸形

【数据集背景】

本数据集源站标题为《Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression》。配套论文《Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression》发表于 PLoS ONE（2014），DOI：10.1371/journal.pone.0098646。源站首次发布：2014-06-04。

【数据内容】

源站原始描述：Rare inherited cardiovascular diseases are frequently caused by mutations in genes that are essential for the formation and/or function of the cardiovasculature. Hereditary Haemorrhagic Telangiectasia is a familial disease of this type. The majority of patients carry mutations in either Endoglin (ENG) or ACVRL1 (also known as ALK1) genes, and the disease is characterized by arteriovenous malformations and persistent haemorrhage. ENG and ACVRL1 encode receptors for the TGFβ superfamily of ligands…

【数据结构与技术规格】

文件数 6 个，合计 18.19 MB。Figure_S2.tif：image/tiff，1.96 MB。Figure_S3.tif：image/tiff，3.56 MB。数据集 DOI：10.1371/journal.pone.0098646。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：anatomy、Cardiovascular anatomy、developmental biology、genetics、Genetics of disease、Model organisms、Animal models、Mouse models、depletion、acvrl1。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Endothelial_Depletion_of_Acvrl1_in_Mice_Leads_to_Arteriovenous_Malformations_Associated_with_Reduced_Endoglin_Expression_/1046352

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Tual-Chalot, Simon; Mahmoud, Marwa; R. Allinson, Kathleen; E. Redgrave, Rachael; Zhai, Zhenhua; Paul Oh, S.; et al. (2016). Endothelial Depletion of Acvrl1 in Mice Leads to Arteriovenous Malformations Associated with Reduced Endoglin Expression. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。