PCSK9抑制剂治疗降低杂合子家族性高胆固醇血症患者DNA损伤水平

资源简介

PCSK9抑制剂治疗降低杂合子家族性高胆固醇血症患者DNA损伤水平

【数据集背景】

本数据集源站标题为《Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor therapy reduces the level of DNA damage in patients with heterozygous familial hypercholesterolemia》。项目资助方：Effects of subtilisin/kexin type 9 proprotein convertase inhibitors on changes in selected epigenetic mechanisms and DNA damage in heterozygous familial hypercholesterolaemia。源站首次发布：2024-11-20。

【数据内容】

源站原始描述：Heterozygous Familial Hypercholesterolaemia (HeFH) is a common autosomal dominant genetic disease (1:300) characterized by elevated LDL-C leading to premature atherosclerosis. Treatment with a PCSK9 inhibitor (iPCSK9) is recommended in high cardiovascular risk FH patients if the treatment goal is not achieved on maximal tolerated statin plus ezetimibe. The aim of this study was to examine the changes in DNA damage in HeFH patients associated with iPCSK9 use. Fifty-seven patients were included: a…

【数据结构与技术规格】

文件数 2 个，合计 27.56 KB。数据集 DOI：10.5281/zenodo.14191600。

【主题与分类】

主题标签：DNA damage、heterozygous familial hypercholesterolemia、PCSK9 inhibitors。

【获取与许可】

源站页面：https://zenodo.org/records/14191600

使用许可：cc-by-4.0。