LDLR基因突变家族性高胆固醇血症患者血清PON1芳酯酶活性降低

资源简介

LDLR基因突变家族性高胆固醇血症患者血清PON1芳酯酶活性降低

【数据集背景】

本数据集源站标题为《Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene》。配套论文《Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene》发表于 Genetics and Molecular Biology（2018），DOI：10.1590/1678-4685-gmb-2016-0287。源站首次发布：2018-07-25。

【数据内容】

源站原始描述：Abstract Paraoxonase 1 (PON1) is a serum enzyme associated with high density lipoprotein (HDL) regulation through its paraoxonase and arylesterase activity. PON1 inhibits the oxidation of HDL and low density lipoprotein (LDL), and is involved in the pathogenesis of a variety of diseases including atherosclerosis. Conversely, mutations in the low density lipoprotein receptor (LDLR) result in failure of receptor mediated endocytosis of LDL leading to its elevated plasma levels and onset of familia…

【数据结构与技术规格】

文件数 5 个，合计 1.16 MB。数据集 DOI：10.6084/m9.figshare.6857438.v1。

【主题与分类】

源站学科分类：Biochemistry and Cell Biology not elsewhere classified、Genetics not elsewhere classified。主题标签：Paraoxonase-1、hypercholesteremia、arylesterase、LDLR mutation。

【适用方向】

源站学科分类标注为 Biochemistry and Cell Biology not elsewhere classified、Genetics not elsewhere classified。

【获取与许可】

源站页面：https://scielo.figshare.com/articles/dataset/Decreased_serum_PON1_arylesterase_activity_in_familial_hypercholesterolemia_patients_with_a_mutated_LDLR_gene/6857438

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Idrees, Muhammad; Siddiq, Abdul Rauf; Ajmal, Muhammad; Akram, Muhammad; Khalid, Rana Rehan; Hussain, Alamdar; et al. (2018). Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene. SciELO journals. Dataset

【使用注意】

· 源站最后修改于 2024-02-06，引用时请注意版本时效。