SPACE试验中年龄与治疗交互作用的统计方法研究

数据集获取（Figshare）

• 源站标题：Investigation of age–treatment interaction in the SPACE trial using different statistical approaches
• DOI：10.6084/m9.figshare.7477574.v2
• 发布日期：2019-06-11
• 文件数：2 个
• 文件总体积：93.66 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/Investigation_of_age_treatment_interaction_in_the_SPACE_trial_using_different_statistical_approaches/7477574

命令行下载

curl -L -o "cjas_a_1558186_sm3046.pdf" "https://ndownloader.figshare.com/files/15428711"
curl -L -o "cjas_a_1558186_sm9724.r" "https://ndownloader.figshare.com/files/13849418"

文件清单

• cjas_a_1558186_sm3046.pdf（64.96 KB）
• cjas_a_1558186_sm9724.r（28.71 KB）

文件总体积 93.66 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Selection of treatments to fit the specific needs for a certain patient is one major challenge in modern medicine. Personalized treatments rely on established patient–treatment interactions. In recent years, various statistical methods for the identification and estimation of interactions between relevant covariates and treatment were proposed. In this article, different available methods for detection and estimation of a covariate–treatment interaction for a time-to-event outcome, namely the standard Cox regression model assuming a linear interaction, the fractional polynomials approach for interaction, the modified outcome approach, the local partial-likelihood approach, and STEPP (Subpopulation Treatment Effect Pattern Plots) were applied to data from the SPACE trial, a randomized clinical trial comparing stent-protected angioplasty (CAS) to carotid endarterectomy (CEA) in patients with symptomatic stenosis, with the aim to analyse the interaction between age and treatment. Time from primary intervention to the first relevant event (any stroke or death) was considered as outcome parameter. The analyses suggest a qualitative interaction between patient age and treatment indicating a lower risk after treatment with CAS compared to CEA for younger patients, while for elderly patients a lower risk after CEA was observed. Differences in the statistical methods regarding the observed results, applicability, and interpretation are discussed.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.7477574.v2（source: https://tandf.figshare.com/articles/dataset/Investigation_of_age_treatment_interaction_in_the_SPACE_trial_using_different_statistical_approaches/7477574）。