CYP2C19和CES1基因变异影响斯里兰卡南亚人群氯吡格雷代谢的数据集

数据集获取（Figshare）

• 源站标题：<i>CYP2C19</i> and <i>CES1</i> gene variants affecting clopidogrel metabolism in a South Asian population from Sri Lanka
• DOI：10.6084/m9.figshare.28208789.v1
• 发布日期：2025-01-15
• 文件数：2 个
• 文件总体积：58.52 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/_i_CYP2C19_i_and_i_CES1_i_gene_variants_affecting_clopidogrel_metabolism_in_a_South_Asian_population_from_Sri_Lanka/28208789

命令行下载

curl -L -o "ipgs_a_2452835_sm6332.docx" "https://ndownloader.figshare.com/files/51685157"
curl -L -o "ipgs_a_2452835_sm6331.docx" "https://ndownloader.figshare.com/files/51685160"

文件清单

• ipgs_a_2452835_sm6332.docx（30.59 KB）
• ipgs_a_2452835_sm6331.docx（27.94 KB）

文件总体积 58.52 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Clopidogrel exhibits substantial variability in therapeutic response, largely contributed by genetic factors. The pharmacogenomic variants data on clopidogrel metabolism in South Asians have been sparsely studied. This study explores the impact of CYP2C19 and CES1 gene variants on clopidogrel metabolism in Sri Lankans, revealing significant pharmacogenomic insights with broader implications for South Asians.
Genotype data were filtered out from an anonymized database of 690 Sri Lankans, and minor allele frequencies (MAFs) were calculated. Five variants of CYP2C19 and one variant of CES1 gene were studied.
Among the five CYP2C19 variants studied, rs12769205 (A>G) and rs4244285 (G>A) had the highest MAF of 42.1% and 42.0%, respectively. The CES1 variant rs71647871 (C>T) showed a MAF of 0.2%. Sri Lankans exhibited significantly higher MAFs for key variants compared to populations such as Europeans, African Americans, and East Asians (p Given that South Asians share genetic similarities, these findings suggest that a substantial proportion of the region’s population may also be poor responders to clopidogrel, increasing the risk of adverse outcomes. This highlights the importance of genotype-guided antiplatelet therapy, which could improve clinical outcomes across South Asia amidst rising cardiovascular disease rates.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.28208789.v1（source: https://tandf.figshare.com/articles/dataset/_i_CYP2C19_i_and_i_CES1_i_gene_variants_affecting_clopidogrel_metabolism_in_a_South_Asian_population_from_Sri_Lanka/28208789）。