使用微流控系统的镁基合金生物降解性与血小板粘附评估

数据集获取（Figshare）

• 源站标题：Biodegradability and platelets adhesion assessment of magnesium-based alloys using a microfluidic system
• DOI：10.1371/journal.pone.0182914
• 发布日期：2017-08-10
• 文件数：5 个
• 文件总体积：8.75 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Biodegradability_and_platelets_adhesion_assessment_of_magnesium-based_alloys_using_a_microfluidic_system/5300599

命令行下载

curl -L -o "S1 Fig.tif" "https://ndownloader.figshare.com/files/9086671"
curl -L -o "S2 Fig.tif" "https://ndownloader.figshare.com/files/9086686"
curl -L -o "S3 Fig.tif" "https://ndownloader.figshare.com/files/9086722"
curl -L -o "S4 Fig.tif" "https://ndownloader.figshare.com/files/9086737"
curl -L -o "S5 Fig.tif" "https://ndownloader.figshare.com/files/9086758"

文件清单

• S1 Fig.tif（532.43 KB）
• S2 Fig.tif（1.05 MB）
• S3 Fig.tif（4.43 MB）
• S4 Fig.tif（2.48 MB）
• S5 Fig.tif（246.77 KB）

文件总体积 8.75 MB（源站 API 实测）。

数据说明

Magnesium (Mg)-based stents are extensively explored to alleviate atherosclerosis due to their biodegradability and relative hemocompatibility. To ensure the quality, safety and cost-efficacy of bioresorbable scaffolds and full utilization of the material tunability afforded by alloying, it is critical to access degradability and thrombosis potential of Mg-based alloys using improved in vitro models that mimic as closely as possible the in vivo microenvironment. In this study, we investigated biodegradation and initial thrombogenic behavior of Mg-based alloys at the interface between Mg alloys’ surface and simulated physiological environment using a microfluidic system. The degradation properties of Mg-based alloys WE43, AZ31, ZWEK-L, and ZWEK-C were evaluated in complete culture medium and their thrombosis potentials in platelet rich plasma, respectively. The results show that 1) physiological shear stress increased the corrosion rate and decreased platelets adhesion rate as compared to static immersion; 2) secondary phases and impurities in material composition induced galvanic corrosion, resulting in higher corrosion resistance and platelet adhesion rate; 3) Mg-based alloys with higher corrosion rate showed higher platelets adhesion rate. We conclude that a microfluidic-based in vitro system allows evaluation of biodegradation behaviors and platelets responses of Mg-based alloys under specific shear stress, and degradability is related to platelets adhesion.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0182914（source: https://plos.figshare.com/articles/dataset/Biodegradability_and_platelets_adhesion_assessment_of_magnesium-based_alloys_using_a_microfluidic_system/5300599）。