临床和社会人口学特征数据

数据集获取（Figshare）

• 源站标题：Clinical and sociodemographic characteristics.
• DOI：10.1371/journal.pone.0306445.t001
• 发布日期：2024-07-11
• 文件数：1 个
• 文件总体积：9.73 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Clinical_and_sociodemographic_characteristics_/26260319

命令行下载

curl -L -o "Table 1.xls" "https://ndownloader.figshare.com/files/47598533"

文件清单

• Table 1.xls（9.73 KB）

文件总体积 9.73 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Clopidogrel is widely used worldwide as an antiplatelet therapy in patients with acute coronary disease. Genetic factors influence interindividual variability in response. Some studies have explored the polygenic contributions in the drug response, generating pharmacogenomic risk scores (PgxPRS). Importantly, these factors are less explored in underrepresented populations, such as Latin-American countries. Identifying patients at risk of high-on-treatment platelet reactivity (HTPR) is highly valuable in translational medicine. In this study we used a custom next-generation sequencing (NGS) panel composed of 91 single nucleotide polymorphisms (SNPs) and 28 genes related to clopidogrel metabolism, to analyze 70 patients with platelet reactivity values, assessed through closure time (CT). Our results demonstrated the association of SNPs with HTPR and non-HTPR, revealing the strongest associations with rs2286823 (OR: 5,0; 95% CI: 1,02–24,48; p: 0,03), rs2032582 (OR: 4,41; 95% CI: 1,20–16,12; p: 0,019), and rs1045642 (OR: 3,38; 95% CI: 0,96–11,9; p: 0,05). Bivariate regression analysis demonstrated the significant association of several SNPs with the CT value, a “surrogate” biomarker of clopidogrel response. Exploratory results from the LASSO regression model showed a high discriminatory capacity between HTPR and non-HTPR patients (AUC: 0,955), and the generated PgxPRS demonstrated a significant negative association between the risk score, CT value, and the condition of HTPR and non-HTPR. To our knowledge, our study addresses for the first time the analysis of the polygenic contribution in platelet reactivity using NGS and establishes PgxPRS derived from the LASSO model. Our results demonstrate the polygenic implication of clopidogrel response and offer insights applicable to the translational medicine of antiplatelet therapy in an understudied population.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0306445.t001（source: https://plos.figshare.com/articles/dataset/Clinical_and_sociodemographic_characteristics_/26260319）。