数据表1：基于抗菌逐层涂层的导尿管药物递送系统（实验与模拟方法）

数据集获取（Figshare）

• 源站标题：Data Sheet 1_Drug delivery system based on an antibacterial layer-by-layer coating on urinary catheters: an experimental and simulation approach.pdf
• DOI：10.3389/fbioe.2025.1614509.s001
• 发布日期：2025-08-29
• 文件数：1 个
• 文件总体积：194.90 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Drug_delivery_system_based_on_an_antibacterial_layer-by-layer_coating_on_urinary_catheters_an_experimental_and_simulation_approach_pdf/30008248

命令行下载

curl -L -o "Data Sheet 1_Drug delivery system based on an antibacterial layer-by-layer coating on urinary catheters: an experimental and simulation approach.pdf" "https://ndownloader.figshare.com/files/57493276"

文件清单

• Data Sheet 1_Drug delivery system based on an antibacterial layer-by-layer coating on urinary catheters: an experimental and simulation approach.pdf（194.90 KB）

文件总体积 194.90 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Urinary catheters (UCs) are critical in biomedical applications, but prolonged use increases the risk of catheter-associated urinary tract infections (CAUTIs), a leading cause of healthcare-associated infections (HAIs). The present study presents a dual strategy to create an antibacterial surface on commercial Foley silicone UCs by combining a contact-killing effect with the controlled release of antimicrobial compounds. We designed a drug delivery system using a layer-by-layer (LbL) antibacterial coating of carboxymethylcellulose (CMC) and chitosan-silver (CHI-Ag) complexes, with ciprofloxacin (CFX) as the model drug. The resulting LbL coating, about 1 μm thick, incorporated Ag0 and demonstrated a high capacity for CFX loading, releasing over twice the amount (70 μg/cm2) compared to uncoated UCs (30 μg/cm2). The antibacterial efficacy was significantly higher in the LbL-coated samples, particularly against S. aureus compared to E. coli. Drug release experiments, modeled using Fick’s second law, indicated a diffusivity of 1.744×10−5 cm2/h. Our mathematical model predicts how variations in drug loading and rest times impact release profiles. Finally, molecular dynamics simulations suggested strong compatibility between CFX and the LbL layers, though with relatively low stability. This dual strategy holds promise for reducing CAUTIs effectively.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fbioe.2025.1614509.s001（source: https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Drug_delivery_system_based_on_an_antibacterial_layer-by-layer_coating_on_urinary_catheters_an_experimental_and_simulation_approach_pdf/30008248）。