Disease Severity and Mortality Can Be Independently Regulated in a Mouse Model of Experimental Graft versus Host Disease
This dataset originates from a mouse study investigating graft versus host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) with high mortality and morbidity rates. Using a semi-allogeneic irradiated chimeric model, the research employed bone marrow-derived dendritic cells (BMDC) from NOD2/CARD15-deficient donors and demonstrated that mortality could be dissociated from disease severity (clinical and pathological scores). The dataset likely includes multimodal data such as survival rates, clinical scoring, histopathological analyses, bacterial translocation assays, hematologic recovery metrics, and epithelial integrity assessments. These data can be used to explore the mechanisms separating death from disease manifestations in GVHD, providing a model for studying transplant-related mortality.
基本信息
About
This dataset originates from a mouse study investigating graft versus host disease (GVHD), a major complication of allogeneic hematopoietic stem cell transplantation (HSCT) with high mortality and morbidity rates. Using a semi-allogeneic irradiated chimeric model, the research employed bone marrow-derived dendritic cells (BMDC) from NOD2/CARD15-deficient donors and demonstrated that mortality could be dissociated from disease severity (clinical and pathological scores). The dataset likely includes multimodal data such as survival rates, clinical scoring, histopathological analyses, bacterial translocation assays, hematologic recovery metrics, and epithelial integrity assessments. These data can be used to explore the mechanisms separating death from disease manifestations in GVHD, providing a model for studying transplant-related mortality.
https://figshare.com/articles/dataset/_Disease_Severity_and_Mortality_Can_Be_Independently_Regulated_in_a_Mouse_Model_of_Experimental_Graft_versus_Host_Disease_/1299823
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数据说明
该数据集源于一项研究移植物抗宿主病（GVHD）的小鼠实验，GVHD是同种异体造血干细胞移植（HSCT）的主要并发症，具有高死亡率和高发病率。研究通过半同种异体照射嵌合体模型，使用NOD2/CARD15缺陷供体来源的骨髓源性树突状细胞（BMDC）进行干预，发现小鼠的死亡率与疾病严重程度（临床和病理评分）可被独立调控。数据集可能包含实验动物的生存数据、临床评分、病理组织学分析、细菌易位检测、造血恢复指标以及上皮完整性评估等多模态数据。这些数据可用于探究GVHD中死亡与疾病表现的分离机制，为移植相关死亡的研究提供模型支持。
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