SCN10A基因突变在红斑性肢痛症患者中增强C纤维活动依赖性减慢

资源简介

SCN10A基因突变在红斑性肢痛症患者中增强C纤维活动依赖性减慢

【数据集背景】

本数据集源站标题为《SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing》。配套论文《SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing》发表于 PLOS ONE（2016），DOI：10.1371/journal.pone.0161789。源站首次发布：2016-09-06。

【数据内容】

源站原始描述：Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia. Mutations in TTX resistant channels, such as Nav1.8 or Nav1.9, were recently connected with inherited chronic pain syndromes. Here, we investigated the effects of the p.M650K mutation in Nav1.8 in a 53 year old patient with erythromelalgia by microneurography and patch-clamp techniques. Recordings of…

【数据结构与技术规格】

文件数 7 个，合计 26.81 MB。S3 Fig.TIF：image/tiff，167.62 KB。数据集 DOI：10.1371/journal.pone.0161789。

【主题与分类】

源站学科分类：Biochemistry、Cell Biology、Genetics、Neuroscience、Biotechnology、Developmental Biology。主题标签：WT、voltage-gated sodium channel、SCN 10A Mutation、p.M 650K mutation、ADS、AP、TTX、Erythromelalgia Enhances C-Fiber Activity Dependent、Nav 1.8、M 650K transfected DRGs。

【适用方向】

源站学科分类标注为 Biochemistry、Cell Biology、Genetics、Neuroscience、Biotechnology、Developmental Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/SCN10A_Mutation_in_a_Patient_with_Erythromelalgia_Enhances_C-Fiber_Activity_Dependent_Slowing/3810519

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Kist, Andreas M.; Sagafos, Dagrun; Rush, Anthony M.; Neacsu, Cristian; Eberhardt, Esther; Schmidt, Roland; et al. (2016). SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。