皮肤红斑狼疮遗传学概况表一

数据集获取（Figshare）

• 源站标题：Table_1_The Genetic Landscape of Cutaneous Lupus Erythematosus.docx
• DOI：10.3389/fmed.2022.916011.s002
• 发布日期：2022-06-02
• 文件数：1 个
• 文件总体积：16.72 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_The_Genetic_Landscape_of_Cutaneous_Lupus_Erythematosus_docx/19956155

命令行下载

curl -L -o "Table_1_The Genetic Landscape of Cutaneous Lupus Erythematosus.docx" "https://ndownloader.figshare.com/files/35512145"

文件清单

• Table_1_The Genetic Landscape of Cutaneous Lupus Erythematosus.docx（16.72 KB）

文件总体积 16.72 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Cutaneous lupus erythematosus (CLE) is an autoimmune connective tissue disease that can exist as a disease entity or within the context of systemic lupus erythematosus (SLE). Over the years, efforts to elucidate the genetic underpinnings of CLE and SLE have yielded a wealth of information. This review examines prior studies investigating the genetics of CLE at the DNA and RNA level and identifies future research areas. In this literature review, we examined the English language literature captured within the MEDLINE and Embase databases using pre-defined search terms. First, we surveyed studies investigating various DNA studies of CLE. We identified three predominant areas of focus in HLA profiling, complement deficiencies, and genetic polymorphisms. An increased frequency of HLA-B8 has been strongly linked to CLE. In addition, multiple genes responsible for mediating innate immune response, cell growth, apoptosis, and interferon response confer a higher risk of developing CLE, specifically TREX1 and SAMHD1. There was a strong association between C2 complement deficiency and CLE. Second, we reviewed literature studying aberrations in the transcriptomes of patients with CLE. We reviewed genetic aberrations initiated by environmental insults, and we examined the interplay of dysregulated inflammatory, apoptotic, and fibrotic pathways in the context of the pathomechanism of CLE. These current learnings will serve as the foundation for further advances in integrating personalized medicine into the care of patients with CLE.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fmed.2022.916011.s002（source: https://frontiersin.figshare.com/articles/dataset/Table_1_The_Genetic_Landscape_of_Cutaneous_Lupus_Erythematosus_docx/19956155）。