氧化应激通过c-Jun/AP-1诱导富含半胱氨酸蛋白61（CCN1）从而降低人真皮成纤维细胞胶原表达

资源简介

氧化应激通过c-Jun/AP-1诱导富含半胱氨酸蛋白61（CCN1）从而降低人真皮成纤维细胞胶原表达

【数据集背景】

本数据集源站标题为《Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts》。配套论文《Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts》发表于 PLoS ONE（2014），DOI：10.1371/journal.pone.0115402。源站首次发布：2014-12-23。

【数据内容】

源站原始描述：Human skin is a primary target of oxidative stress from reactive oxygen species (ROS) generated from both extrinsic and intrinsic sources. Oxidative stress inhibits the production of collagen, the most abundant protein in skin, and thus contributes to connective tissue aging. Here we report that cysteine-rich protein 61 (CCN1), a negative regulator of collagen production, is markedly induced by ROS and mediates loss of type I collagen in human dermal fibroblasts. Conversely, antioxidant N-acetyl…

【数据结构与技术规格】

文件数 3 个，合计 2.81 MB。S1_Figure.eps：application/postscript，1.04 MB。S2_Figure.eps：application/postscript，853.49 KB。S3_Figure.eps：application/postscript，911.69 KB。数据集 DOI：10.1371/journal.pone.0115402。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：Human Dermal Fibroblasts Human skin、mediates loss、protein、Collagen Expression、tissue、collagen production、ros、type、CCN 1 promoter、fibroblast。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Oxidant_Exposure_Induces_Cysteine_Rich_Protein_61_CCN1_via_c_Jun_AP_1_to_Reduce_Collagen_Expression_in_Human_Dermal_Fibroblasts_/1278013

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Qin, Zhaoping; Robichaud, Patrick; He, Tianyuan; Fisher, Gary J.; J. Voorhees, John; Quan, Taihao (2016). Oxidant Exposure Induces Cysteine-Rich Protein 61 (CCN1) via c-Jun/AP-1 to Reduce Collagen Expression in Human Dermal Fibroblasts. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。