氧浓度调控家族性副神经节瘤模型的表观遗传效应

资源简介

氧浓度调控家族性副神经节瘤模型的表观遗传效应

【数据集背景】

本数据集源站标题为《Oxygen Concentration Controls Epigenetic Effects in Models of Familial Paraganglioma》。配套论文《Oxygen Concentration Controls Epigenetic Effects in Models of Familial Paraganglioma》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0127471。源站首次发布：2015-05-18。

【数据内容】

源站原始描述：Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the genes encoding the subunits of succinate dehydrogenase (SDH), a tricarboxylic acid (TCA) cycle enzyme. For unknown reasons, a higher prevalence of PGL has been reported for humans living at higher altitude, with increased disease aggressiveness and morbidity. In this study, we evaluate the effects of oxygen on epigenetic changes due to succinate accumulation in three SDH loss cell culture models. We test…

【数据结构与技术规格】

文件数 9 个，合计 16.25 MB。S1_Fig.tif：image/tiff，918.25 KB。S2_Fig.tif：image/tiff，1.12 MB。S3_Fig.tif：image/tiff，1.47 MB。数据集 DOI：10.1371/journal.pone.0127471。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：SDH loss cell culture models、hypoxia、succinate accumulation、succinate accumulation synergistically、tca、dioxygenase、Oxygen Concentration Controls Epigenetic Effects、dna、kg、pgl。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Oxygen_Concentration_Controls_Epigenetic_Effects_in_Models_of_Familial_Paraganglioma_/1418652

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：F. Her, Yeng; Nelson-Holte, Molly; James Maher III, Louis (2016). Oxygen Concentration Controls Epigenetic Effects in Models of Familial Paraganglioma. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。