朊病毒急性突触毒性主要由蛋白酶抗性PrPSc物种驱动

资源简介

朊病毒急性突触毒性主要由蛋白酶抗性PrPSc物种驱动

【数据集背景】

本数据集源站标题为《Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species》。配套论文《Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species》发表于 PLOS Pathogens（2018），DOI：10.1371/journal.ppat.1007214。源站首次发布：2018-08-08。

【数据内容】

源站原始描述：Although misfolding of normal prion protein (PrPC) into abnormal conformers (PrPSc) is critical for prion disease pathogenesis our current understanding of the underlying molecular pathophysiology is rudimentary. Exploiting an electrophysiology paradigm, herein we report that at least modestly proteinase K (PK)-resistant PrPSc (PrPres) species are acutely synaptotoxic. Brief exposure to ex vivo PrPSc from two mouse-adapted prion strains (M1000 and MU02) prepared as crude brain homogenates (cM100…

【数据结构与技术规格】

文件数 7 个，合计 5.11 MB。ppat.1007214.s001.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，74.39 KB。ppat.1007214.s002.tif：image/tiff，1.03 MB。ppat.1007214.s003.tif：image/tiff，1.21 MB。数据集 DOI：10.1371/journal.ppat.1007214。

【主题与分类】

源站学科分类：Biochemistry、Cell Biology、Molecular Biology、Neuroscience、Infectious Diseases、Computational Biology。主题标签：PrP C knockout、LTP disruption approximating、WT、PTP、prion disease pathogenesis、MU、protease-resistant PrP Sc species、murine prion disease、mouse-adapted prion strains、vivo PrP Sc。

【适用方向】

源站学科分类标注为 Biochemistry、Cell Biology、Molecular Biology、Neuroscience、Infectious Diseases、Computational Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Prion_acute_synaptotoxicity_is_largely_driven_by_protease-resistant_PrP_sup_Sc_sup_species/6949475

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Foliaki, Simote Totauhelotu; Lewis, Victoria; Finkelstein, David Isaac; Lawson, Victoria; Coleman, Harold Arthur; Senesi, Matteo; et al. (2018). Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species. PLOS Pathogens. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。