MRI引导激光间质热疗法与手术治疗颞叶内侧癫痫的早期经济学评估

数据集获取（Figshare）

• 源站标题：Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy
• DOI：10.1371/journal.pone.0224571
• 发布日期：2019-11-20
• 文件数：6 个
• 文件总体积：2.01 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Early_economic_evaluation_of_MRI-guided_laser_interstitial_thermal_therapy_MRgLITT_and_epilepsy_surgery_for_mesial_temporal_lobe_epilepsy/10564796

命令行下载

curl -L -o "pone.0224571.s001.docx" "https://ndownloader.figshare.com/files/19067117"
curl -L -o "pone.0224571.s002.docx" "https://ndownloader.figshare.com/files/19067120"
curl -L -o "pone.0224571.s003.tif" "https://ndownloader.figshare.com/files/19067123"
curl -L -o "pone.0224571.s004.tif" "https://ndownloader.figshare.com/files/19067126"
curl -L -o "pone.0224571.s005.tif" "https://ndownloader.figshare.com/files/19067129"
curl -L -o "pone.0224571.s006.tif" "https://ndownloader.figshare.com/files/19067132"

文件清单

• pone.0224571.s001.docx（18.75 KB）
• pone.0224571.s002.docx（12.49 KB）
• pone.0224571.s003.tif（574.04 KB）
• pone.0224571.s004.tif（494.40 KB）
• pone.0224571.s005.tif（484.62 KB）
• pone.0224571.s006.tif（429.46 KB）

文件总体积 2.01 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
MRI-guided laser interstitial thermal therapy (MRgLITT) is a new minimally invasive treatment for temporal lobe epilepsy (TLE), with limited effectiveness data. It is unknown if the cost savings associated with shorter hospitalization could offset the high equipment cost of MRgLITT. We examined the cost-utility of MRgLITT versus surgery for TLE from healthcare payer perspective, and the value of additional research to inform policy decision on MRgLITT.
Methods
We developed a microsimulation model to evaluate quality adjusted life years (QALYs), costs, and incremental cost-effectiveness ratio (ICER) of MRgLITT versus surgery in TLE, assuming life-time horizon and 1.5% discount rate. Model inputs were derived from the literature. We conducted threshold and sensitivity analyses to examine parameter uncertainties, and expected value of partial perfect information analyses to evaluate the expected monetary benefit of eliminating uncertainty on probabilities associated with MRgLITT.
Results
MRgLITT yielded 0.08 more QALYs and cost $7,821 higher than surgery, with ICER of $94,350/QALY. Influential parameters that could change model outcomes include probabilities of becoming seizure-free from disabling seizures state and returning to disabling seizures from seizure-free state 5 years after surgery and MRgLITT, cost of MRgLITT disposable equipment, and utilities of disabling seizures and seizure-free states of surgery and MRgLITT. The cost-effectiveness acceptability curve showed surgery was preferred in more than 50% of iterations. The expected monetary benefit of eliminating uncertainty for probabilities associated with MRgLITT was higher than for utilities associated with MRgLITT.
Conclusions
MRgLITT resulted in more QALYs gained and higher costs compared to surgery in the base-case. The model was sensitive to variations in the cost of MRgLITT disposable equipment. There is value in conducting more research to reduce uncertainty on the probabilities and utilities of MRgLITT, but priority should be given to research focusing on improving the precision of estimates on effectiveness of MRgLITT.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0224571（source: https://plos.figshare.com/articles/dataset/Early_economic_evaluation_of_MRI-guided_laser_interstitial_thermal_therapy_MRgLITT_and_epilepsy_surgery_for_mesial_temporal_lobe_epilepsy/10564796）。