FAM83家族成员在胃癌中的预后生物标志物和治疗靶点综合分析数据表10
胃癌（STAD）中FAM83家族预后生物标志物与治疗靶点综合分析的数据表10，整合多数据库分析表达、突变、预后模型和免疫浸润。
基本信息
资源简介
FAM83家族成员在胃癌中的预后生物标志物和治疗靶点综合分析数据表10
【一句话概览】
本数据集是 figshare 公开的结构化表格数据集，收录 1 个文件、合计 496.43 KB，主题涵盖 gastric cancer、FAM83 family members、prognostic biomarker、lasso regression analysis、nomogram prognostic model，可用于统计建模、特征工程与队列分析，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Data_Sheet_10_Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.ZIP》。配套论文《Gene Expression Signature–Based Prognostic Risk Score in Gastric Cancer》发表于 Clinical Cancer Research（2011），DOI：10.1158/1078-0432.ccr-10-2180。源站首次发布：2021-11-19。
【数据内容】
源站原始描述：Background: Gastric cancer (GC) is one of the most common and poor prognosis malignancy in the world. The Family with sequence similarity 83 (FAM83) comprises of eight members of A–H. Accumulating evidence confirmed important roles for FAM83 family in tumorigenesis and progression. However, the prognostic values of FAM83 family in GC still have not been clarified. Methods: ONCOMINE, UALCAN, GEPIA, THE HUMAN PROTEIN ATLAS, Kaplan–Meier Plotter, cBioPortal, DAVID, STRING and TIMER databases and R…
中文译文（机器翻译，仅供快速理解，请以原文为准）：背景：胃癌（GC）是世界上最常见且预后较差的恶性肿瘤之一。序列相似性83家族（FAM83）由A–H八个成员组成。越来越多的证据证实FAM83家族在肿瘤发生和进展中发挥重要作用。然而，FAM83家族在GC中的预后价值仍未明确。 方法：本研究采用了ONCOMINE、UALCAN、GEPIA、THE HUMAN PROTEIN ATLAS、Kaplan–Meier Plotter、cBioPortal、DAVID、STRING和TIMER数据库以及R软件。 结果：在本研究中，我们证明FAM83 B/C/D/H的mRNA水平在胃腺癌（STAD）中显著上调，但FAM83G/H的蛋白水平在STAD中显著较低。随后，FAM83C/D/G/H与STAD患者的肿瘤分期显著相关。然后，FAM83家族成员在STAD患者中的突变率为46%，其中突变率最高的是FAM83H（23%）。此外，FAM83家族及其259个共表达基因的功能主要与志贺菌病、RNA降解和真核生物中的核糖体生物发生途径相关。此外，我们建立了FAM83家族在STAD中的预后模型，包括STAD患者预后模型（FAM83C/D/G）、伴淋巴结转移的STAD（FAM83C/D/G/H）以及ERBB2高表达的STAD（FAM83G/H）。FAM83C/D高表达与STAD预后不良相关，而FAM83G/H高表达与STAD预后良好相关。此外，我们发现FAM83C/D/G/H的表达与六种免疫细胞的浸润显著相关[B细胞、CD8+T细胞、CD4+T细胞、巨噬细胞和髓样树突状细胞（DC）]，而当FAM83C低表达且FAM83D高表达时，CD4+T细胞和巨噬细胞具有更高的风险评分（HR > 1）。当FAM83G低表达且FAM83H高表达时，NK细胞的风险评分显著降低（HR 结论：这些发现表明，FAM83C/D/G/H可能在STAD肿瘤发生和进展中发挥关键作…
【数据结构与技术规格】
文件数 1 个，合计 496.43 KB。Data_Sheet_10_Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.ZIP：application/zip，496.43 KB。数据集 DOI：10.3389/fcell.2021.719613.s002。
【主题与分类】
源站学科分类：Cell Biology、Cell Development, Proliferation and Death、Cell Metabolism、Cell Neurochemistry、Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)、Marine Biology。主题标签：gastric cancer、FAM83 family members、prognostic biomarker、lasso regression analysis、nomogram prognostic model、immune cell infiltration。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/Data_Sheet_10_Comprehensive_Analysis_and_Identification_of_Prognostic_Biomarkers_and_Therapeutic_Targets_Among_FAM83_Family_Members_for_Gastric_Cancer_ZIP/17048771
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Zhang, Tianhao; Lai, Shurong; Cai, Yuzhi; Huang, Zhixin; Li, Ying; Chen, Sile; et al. (2021). Data_Sheet_10_Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.ZIP. Frontiers. Dataset
【使用注意】
· 源站最后修改于 2023-06-06，引用时请注意版本时效。
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使用方式
数据集获取（Figshare）
- 源站标题：Data_Sheet_10_Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.ZIP
- DOI：10.3389/fcell.2021.719613.s002
- 发布日期：2021-11-19
- 文件数：1 个
- 文件总体积：496.43 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/Data_Sheet_10_Comprehensive_Analysis_and_Identification_of_Prognostic_Biomarkers_and_Therapeutic_Targets_Among_FAM83_Family_Members_for_Gastric_Cancer_ZIP/17048771
命令行下载
curl -L -o "Data_Sheet_10_Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.ZIP" "https://ndownloader.figshare.com/files/31530344"
文件清单
Data_Sheet_10_Comprehensive Analysis and Identification of Prognostic Biomarkers and Therapeutic Targets Among FAM83 Family Members for Gastric Cancer.ZIP（496.43 KB）
文件总体积 496.43 KB（源站 API 实测）。
数据说明
Background: Gastric cancer (GC) is one of the most common and poor prognosis malignancy in the world. The Family with sequence similarity 83 (FAM83) comprises of eight members of A–H. Accumulating evidence confirmed important roles for FAM83 family in tumorigenesis and progression. However, the prognostic values of FAM83 family in GC still have not been clarified.
Methods: ONCOMINE, UALCAN, GEPIA, THE HUMAN PROTEIN ATLAS, Kaplan–Meier Plotter, cBioPortal, DAVID, STRING and TIMER databases and R software were adopted in this study.
Results: In this study, we demonstrated that the mRNA levels of FAM83 B/C/D/H were significantly up-regulated in stomach adenocarcinoma (STAD), but the protein level of FAM83G/H were remarkable lowly in STAD. Next, FAM83C/D/G/H were significantly associated with tumor stages in STAD patients. Then, the mutation rate of FAM83 family members in STAD patients was 46%, and the highest mutation rate was FAM83H (23%). Furthermore, the functions of FAM83 family and their 259 co-expression genes were primarily related to Shigellosis, RNA degradation and Ribosome biogenesis in eukaryotes pathway. Besides, we have established the prognostic model of FAM83 family in STAD, including the prognostic model of STAD patients (FAM83C/D/G), STAD with lymph node metastasis (FAM83C/D/G/H) and STAD with ERBB2 high expression (FAM83G/H). FAM83C/D high expression with a poor prognosis, while FAM83G/H high expression with a favorable prognosis of STAD. Additionally, we found that the expression of FAM83C/D/G/H were significantly correlated with the infiltration of six types of immune cells [B cells, CD8+T cells, CD4+T cells, macrophages and Myeloid dendritic cells (DC)], whereas CD4+T cells and Macrophage cells have higher risk scores (HR > 1) when FAM83C lowly expression and FAM83D highly expression. The risk score of NK cells was significantly reduced when FAM83G lowly expression and FAM83H highly expression (HR Conclusion: These findings suggested that FAM83C/D/G/H might play key roles in STAD tumorigenesis and progression, and FAM83C/D might be risk factors but FAM83G/H might be favorable prognostic factors for STAD patients. In addition, CD4+T cells and M
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fcell.2021.719613.s002（source: https://frontiersin.figshare.com/articles/dataset/Data_Sheet_10_Comprehensive_Analysis_and_Identification_of_Prognostic_Biomarkers_and_Therapeutic_Targets_Among_FAM83_Family_Members_for_Gastric_Cancer_ZIP/17048771）。
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