中低收入国家儿科神经病理学实践：机构结对能力建设表格1

数据集获取（Figshare）

• 源站标题：Table_1_Pediatric neuropathology practice in a low- and middle-income country: capacity building through institutional twinning.xlsx
• DOI：10.3389/fonc.2024.1328374.s001
• 发布日期：2024-05-03
• 文件数：1 个
• 文件总体积：25.13 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_Pediatric_neuropathology_practice_in_a_low-_and_middle-income_country_capacity_building_through_institutional_twinning_xlsx/25744746

命令行下载

curl -L -o "Table_1_Pediatric neuropathology practice in a low- and middle-income country: capacity building through institutional twinning.xlsx" "https://ndownloader.figshare.com/files/46064472"

文件清单

• Table_1_Pediatric neuropathology practice in a low- and middle-income country: capacity building through institutional twinning.xlsx（25.13 KB）

文件总体积 25.13 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

BackgroundAccurate and precise diagnosis is central to treating central nervous system (CNS) tumors, yet tissue diagnosis is often a neglected focus in low- and middle-income countries (LMICs). Since 2016, the WHO classification of CNS tumors has increasingly incorporated molecular biomarkers into the diagnosis of CNS tumors. While this shift to precision diagnostics promises a high degree of diagnostic accuracy and prognostic precision, it has also resulted in increasing divergence in diagnostic and management practices between LMICs and high-income countries (HICs). Pathologists and laboratory professionals in LMICs lack the proper training and tools to join the molecular diagnostic revolution. We describe the impact of a 7-year long twinning program between Canada and Pakistan on pathology services.
MethodsDuring the study period, 141 challenging cases of pediatric CNS tumors initially diagnosed at Aga Khan University Hospital (AKUH), Karachi, were sent to the Hospital for Sick Children in Toronto, Canada (SickKids), for a second opinion. Each case received histologic review and often immunohistochemical staining and relevant molecular testing. A monthly multidisciplinary online tumor board (MDTB) was conducted to discuss the results with pathologists from both institutions in attendance.
ResultsDiagnostic discordance was seen in 30 cases. Expert review provided subclassification for 53 cases most notably for diffuse gliomas and medulloblastoma. Poorly differentiated tumors benefited the most from second review, mainly because of the resolving power of specialized immunohistochemical stains, NanoString, and targeted gene panel next-generation sequencing. Collaboration with expert neuropathologists led to validation of over half a dozen immunostains at AKUH facilitating diagnosis of CNS tumors.
ConclusionsLMIC-HIC Institutional twinning provides much-needed training and mentorship to pathologists and can help in infrastructure development by adopting and validating new immunohistochemical stains. Persistent unresolved cases indicate that molecular techniques are indispensable in for diagnosis in a minority of cases. The development of affordable alternative mo

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fonc.2024.1328374.s001（source: https://frontiersin.figshare.com/articles/dataset/Table_1_Pediatric_neuropathology_practice_in_a_low-_and_middle-income_country_capacity_building_through_institutional_twinning_xlsx/25744746）。