卵巢癌一线和二线贝伐珠单抗：比利时成本效用分析

数据集获取（Figshare）

• 源站标题：First- and second-line bevacizumab in ovarian cancer: A Belgian cost-utility analysis
• DOI：10.1371/journal.pone.0195134
• 发布日期：2018-04-09
• 文件数：3 个
• 文件总体积：674.79 KB
• 源站页面：https://plos.figshare.com/articles/dataset/First-_and_second-line_bevacizumab_in_ovarian_cancer_A_Belgian_cost-utility_analysis/6117071

命令行下载

curl -L -o "S1 Table.docx" "https://ndownloader.figshare.com/files/11029934"
curl -L -o "S1 Fig.docx" "https://ndownloader.figshare.com/files/11029943"
curl -L -o "S2 Fig.docx" "https://ndownloader.figshare.com/files/11029946"

文件清单

• S1 Table.docx（19.71 KB）
• S1 Fig.docx（151.94 KB）
• S2 Fig.docx（503.15 KB）

文件总体积 674.79 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Currently, in Belgium, bevacizumab is reimbursed for ovarian cancer patients, based on a contract between the Minister and the manufacturer including confidential agreements. This reimbursement will be re-evaluated in 2018.
Objective
To support the reimbursement reassessment by calculating the cost-effectiveness of bevacizumab: (1) in addition to first-line chemotherapy; (2) in the treatment of recurrent ovarian cancer (platinum-sensitive or platinum-resistant).
Methods
A health economic model has been developed for the Belgian situation according to the Belgian guidelines for economic evaluations. The lifetime Markov model was set up from the perspective of the health care payer (government and patient), including direct healthcare related costs. Results are expressed as the extra costs per quality-adjusted life year (QALY). Calculations were based on results of four international trials. Both probabilistic and one-way sensitivity analyses were performed.
Results
Incremental cost-effectiveness ratios (ICERs) of first-line bevacizumab are on average 158 000/QALY (GOG-0218 trial) and 443 000/QALY (ICON7 trial). The most favourable scenario is based on the stage IV subgroup of the GOG-0218 trial (€52 000/QALY). Since subgroup findings are often exploratory and require confirmatory studies, results of the economic evaluation based on this subgroup analysis should be considered with caution. For second-line bevacizumab, ICERs are on average €587 000/QALY (OCEANS trial) and €172 000/QALY (AURELIA trial). Sensitivity analysis shows that results are most sensitive to the price of bevacizumab.
Conclusion
From a health economic perspective, ICERs of bevacizumab are relatively high. The most favourable results are found for first-line treatment of stage IV ovarian cancer patients. Price reductions have a major impact on the estimated ICERs. It is recommended to take these findings into account when re-evaluating the reimbursement of bevacizumab in ovarian cancer.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0195134（source: https://plos.figshare.com/articles/dataset/First-_and_second-line_bevacizumab_in_ovarian_cancer_A_Belgian_cost-utility_analysis/6117071）。