通过诱导多能干细胞(iPS细胞)永生化NF1杂合与NF1纯合阴性丛状神经纤维瘤来源肿瘤细胞

数据集获取

源站：https://synapse.org/Synapse:syn7231973

标准获取流程：

1. 访问源站链接，注册/登录账号；
2. 进入数据集详情页，按页面指引申请权限或直接下载；
3. 部分平台提供 SDK，例如：
   • OpenDataLab: pip install openxlab 后 openxlab.dataset.get(...)
   • ModelScope: pip install modelscope 后 modelscope download
   • 天池: 登录后页面提供直链下载
     以源站「数据下载/使用文档」页面为准。

数据说明

##Perpetuating NF1+/- and NF1-/- plexiform neurofibroma-derived tumor cells through the generation of induced pluripotent stem (iPS) cells Initiative: Cell Culture Name: Eduard Serra, Ph.D. Contact Email: eserra@igtp.cat Dates: 5-1-13 to 8-31-15 Tumor Focus: Plexiform Neurofibroma Application: Preclinical Translational models Background: Neurofibromatosis type 1 (NF1) associated neurofibromas are benign tumors of the peripheral nerves that are difficult to study due to their heterogeneous cellular composition and their genetic heterogeneity regarding the NF1 mutational status of the different cell types. Plexiform neurofibromas (pNFs) differ from discrete neurofibromas (dNFs) in their moment of appearance (though to be congenital in pNFs), the importance of the extension of the nerve and tissues affected (larger in pNFs) and their potential to progress to malignancy, not present in dNFs. Regarding genomics and transcriptomics, Schwann cells (SC) derived from dNFs and pNFs are very much alike. So what is different among these tumors that confer pNFs a risk to become malignant? The extent of affected tissue? The location? The temporal window at which a neural crest-derived cell committed to the SC lineage acquires a double inactivation of the NF1 gene? A particular cellular composition? A combination of factors? Goals and Specific Aims: * Explore the degree of genomic, molecular and cellular variation within a whole plexiform neurofibroma (pNF). * Obtain, authenticate and characterize NF1-/- and NF1+/- induced pluripotent stem cells (iPSC) derived from pNFs. Publications: a manuscript describing this work is currently in progress. ${buttonlink?text=Back to the NTAP Data Portal&url=https%3A%2F%2Fwww%2Esynapse%2Eorg%2F%23%21Synapse%3Asyn4939478} 3- Download the data here Data Organization This repository contains the raw data and analysis results of the “NF1 Plexiform Neurofibroma-derived Tumor Cells” NTAP project. ###F

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。