RNA干扰技术揭示细胞周期蛋白D1作为套细胞淋巴瘤潜在治疗靶点

资源简介

RNA干扰技术揭示细胞周期蛋白D1作为套细胞淋巴瘤潜在治疗靶点

【数据集背景】

本数据集源站标题为《RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma》。配套论文《RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma》发表于 PLoS ONE（2012），DOI：10.1371/journal.pone.0043343。源站首次发布：2012-08-14。

【数据内容】

源站原始描述：Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardat…

【数据结构与技术规格】

文件数 5 个，合计 6.31 MB。Figure_S1.tif：image/tiff，275.29 KB。Figure_S2.tif：image/tiff，1.58 MB。Figure_S3.tif：image/tiff，1.38 MB。数据集 DOI：10.1371/journal.pone.0043343。

【主题与分类】

源站学科分类：Biochemistry、Cell Biology、Hematology、Pharmacology。主题标签：rna、inhibition、highlights、cyclin、d1、therapeutic、mantle、lymphoma。

【适用方向】

源站学科分类标注为 Biochemistry、Cell Biology、Hematology、Pharmacology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/RNA_Inhibition_Highlights_Cyclin_D1_as_a_Potential_Therapeutic_Target_for_Mantle_Cell_Lymphoma/121250

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Weinstein, Shiri; Emmanuel, Rafi; M. Jacobi, Ashley; Abraham, Avigdor; Behlke, Mark A.; Sprague, Andrew G.; et al. (2016). RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。