英国背景下子宫内膜癌女性林奇综合征反射性检测的成本效益分析数据集

数据集获取（Figshare）

• 源站标题：Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting
• DOI：10.1371/journal.pone.0221419
• 发布日期：2019-08-30
• 文件数：7 个
• 文件总体积：1.60 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Cost-effectiveness_analysis_of_reflex_testing_for_Lynch_syndrome_in_women_with_endometrial_cancer_in_the_UK_setting/9753884

命令行下载

curl -L -o "pone.0221419.s001.docx" "https://ndownloader.figshare.com/files/17473301"
curl -L -o "pone.0221419.s002.docx" "https://ndownloader.figshare.com/files/17473304"
curl -L -o "pone.0221419.s003.docx" "https://ndownloader.figshare.com/files/17473307"
curl -L -o "pone.0221419.s004.docx" "https://ndownloader.figshare.com/files/17473310"
curl -L -o "pone.0221419.s005.docx" "https://ndownloader.figshare.com/files/17473313"
curl -L -o "pone.0221419.s006.docx" "https://ndownloader.figshare.com/files/17473316"
curl -L -o "pone.0221419.s007.docx" "https://ndownloader.figshare.com/files/17473319"

文件清单

• pone.0221419.s001.docx（58.59 KB）
• pone.0221419.s002.docx（219.76 KB）
• pone.0221419.s003.docx（308.17 KB）
• pone.0221419.s004.docx（159.64 KB）
• pone.0221419.s005.docx（218.44 KB）
• pone.0221419.s006.docx（127.93 KB）
• pone.0221419.s007.docx（505.44 KB）

文件总体积 1.60 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Lynch syndrome is a hereditary cancer syndrome caused by constitutional pathogenic variants in the DNA mismatch repair (MMR) system, leading to increased risk of colorectal, endometrial and other cancers. The study aimed to identify the incremental costs and consequences of strategies to identify Lynch syndrome in women with endometrial cancer.
Methods
A decision-analytic model was developed to evaluate the relative cost-effectiveness of reflex testing strategies for identifying Lynch syndrome in women with endometrial cancer taking the NHS perspective and a lifetime horizon. Model input parameters were sourced from various published sources. Consequences were measured using quality-adjusted life years (QALYs). A cost-effectiveness threshold of £20 000/QALY was used.
Results
Reflex testing for Lynch syndrome using MMR immunohistochemistry and MLH1 methylation testing was cost-effective versus no testing, costing £14 200 per QALY gained. There was uncertainty due to parameter imprecision, with an estimated 42% chance this strategy is not cost-effective compared with no testing. Age had a significant impact on cost-effectiveness, with testing not predicted to be cost-effective in patients aged 65 years and over.
Conclusions
Testing for Lynch syndrome in younger women with endometrial cancer using MMR immunohistochemistry and MLH1 methylation testing may be cost-effective. Age cut-offs may be controversial and adversely affect implementation.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0221419（source: https://plos.figshare.com/articles/dataset/Cost-effectiveness_analysis_of_reflex_testing_for_Lynch_syndrome_in_women_with_endometrial_cancer_in_the_UK_setting/9753884）。