PD-L1阴性NSCLC患者免疫治疗策略疗效比较数据集

基于23项随机对照试验的PD-L1阴性非小细胞肺癌免疫治疗策略疗效比较数据集,包含生存数据。

Yi, Minhan; Ding, Kaiyue; Zhang, Yuan; Liang, Hui; Li, ZhongkuiYi, Minhan; Ding, Kaiyue; Zhang, Yuan; Liang, Hui; Li, Zhongkui
Taylor & Francis Group
2024-02-12 更新
浏览 20
表格Immune checkpoint inhibitorsnegative PD-L1 expressionNSCLCoverall survivalProgression-free survival
Efficacy comparison of immune treating strategies for NSCLC patients with negative PD-L1 expression

基本信息

模态
表格
大小
0.000915538 GB
许可
CC BY 4.0
创建/更新时间
2024-02-12
版本
v1

资源简介

PD-L1阴性NSCLC患者免疫治疗策略疗效比较数据集

【一句话概览】

本数据集是 figshare 公开的结构化表格数据集,收录 2 个文件、合计 915.54 KB,主题涵盖 Immune checkpoint inhibitors、negative PD-L1 expression、NSCLC、overall survival、Progression-free survival,可用于统计建模、特征工程与队列分析,CC BY 4.0 许可开放获取。

【数据集背景】

本数据集源站标题为《Efficacy comparison of immune treating strategies for NSCLC patients with negative PD-L1 expression》。配套论文《Efficacy comparison of immune treating strategies for NSCLC patients with negative PD-L1 expression》发表于 Expert Review of Clinical Immunology(2022),DOI:10.1080/1744666X.2022.2088510。项目资助方:This research was supported by the Hunan Provincial Natural Science Foundation of China (No. 2020JJ5951, No. 2021JJ80079), the Youth Science Foundation of Xiangya Hospital (No. 2019Q17), the Degree & Postgraduate Education Reform Project of Central South University (No. 2021YJSKSA10), the Undergraduate Education Reform Project of Central South University (No. 2021CG065, No. 2021CG068) and the Research Project of Laboratory Construction and Management of Central South University (No. 202120).。源站首次发布:2022-06-15。

【数据内容】

源站原始描述:We intended to compare and grade the proposed immune treating strategies for non-small cell lung cancer (NSCLC) with negative Programmed Cell Death Ligand 1(PD-L1). We compared the efficacy of single immune checkpoint inhibitor (ICI), single ICI plus chemotherapy, and doublet ICIs with chemotherapy alone, as well as single ICI plus radiotherapy with single ICI for negative PD-L1 (We included 23 randomized control trials with 4665 patients. Compared with chemotherapy alone, single ICI, single ICI…

【数据结构与技术规格】

文件数 2 个,合计 915.54 KB。ierm_a_2088510_sm1581.docx:application/vnd.openxmlformats-officedocument.wordprocessingml.document,899.79 KB。ierm_a_2088510_sm1578.docx:application/vnd.openxmlformats-officedocument.wordprocessingml.document,15.75 KB。数据集 DOI:10.6084/m9.figshare.20071677.v1。

【主题与分类】

源站学科分类:Medicine、Microbiology、Molecular Biology、Pharmacology、Immunology、Mathematical Sciences not elsewhere classified。主题标签:Immune checkpoint inhibitors、negative PD-L1 expression、NSCLC、overall survival、Progression-free survival。

【适用方向】

结构化表格数据可直接用于统计建模、特征工程与队列分析。

【获取与许可】

源站页面:https://tandf.figshare.com/articles/dataset/Efficacy_comparison_of_immune_treating_strategies_for_NSCLC_patients_with_negative_PD-L1_expression/20071677

使用许可:CC BY 4.0(https://creativecommons.org/licenses/by/4.0/)。

规范引用:Efficacy comparison of immune treating strategies for NSCLC patients with negative PD-L1 expression. Taylor & Francis. Ding, Kaiyue; Yi, Minhan; Liang, Hui; Li, Zhongkui; Zhang, Yuan

【使用注意】

· 源站最后修改于 2024-02-12,引用时请注意版本时效。

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下载信息

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需要注册 Kaggle 账号并登录后下载,适合需要跟踪下载记录和使用 API 的用户。

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使用方式

数据集获取(Figshare)

命令行下载

curl -L -o "ierm_a_2088510_sm1581.docx" "https://ndownloader.figshare.com/files/35904471"
curl -L -o "ierm_a_2088510_sm1578.docx" "https://ndownloader.figshare.com/files/35904474"

文件清单

  • ierm_a_2088510_sm1581.docx(899.79 KB)
  • ierm_a_2088510_sm1578.docx(15.75 KB)

文件总体积 915.54 KB(源站 API 实测)。

数据说明

We intended to compare and grade the proposed immune treating strategies for non-small cell lung cancer (NSCLC) with negative Programmed Cell Death Ligand 1(PD-L1).
We compared the efficacy of single immune checkpoint inhibitor (ICI), single ICI plus chemotherapy, and doublet ICIs with chemotherapy alone, as well as single ICI plus radiotherapy with single ICI for negative PD-L1 (We included 23 randomized control trials with 4665 patients. Compared with chemotherapy alone, single ICI, single ICI plus chemotherapy and doublet ICIs all showed a better OS (0.84 [0.71, 0.99] ; 0.77 [0.69, 0.85] ; 0.64 [0.53, 0.77])), while single ICI plus chemotherapy and doublet ICIs showed a better PFS (0.68 [0.61, 0.75] ; 0.69 [0.56, 0.85]). Additionally, single ICI plus radiotherapy obtained a greater pooled PFS (0.49 [0.28–0.87]) than single ICI.
Both single ICI plus chemotherapy and doublet ICIs were probably better treatment decisions than chemotherapy alone for negative PD-L1 NSCLC patients. Also, single ICI plus radiotherapy carved out a new strategy.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.20071677.v1(source: https://tandf.figshare.com/articles/dataset/Efficacy_comparison_of_immune_treating_strategies_for_NSCLC_patients_with_negative_PD-L1_expression/20071677)。

需要用于商业化训练或医疗器械注册(NMPA/FDA)?

公开数据往往缺乏完整的病理回证与专家标注。千方医数集依托陕川双基地与超十家三甲医院直连,提供完全合规、去标识化、支持注册级质控的专病数据集交易服务。