数据表1：肝细胞癌预后分层分析中DNA损伤响应与修复相关基因对特征的识别

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• 源站标题：DataSheet1_Identification of a DNA Damage Response and Repair-Related Gene-Pair Signature for Prognosis Stratification Analysis in Hepatocellular Carcinoma.docx
• DOI：10.3389/fphar.2022.857060.s001
• 发布日期：2022-04-11
• 文件数：1 个
• 文件总体积：1.92 MB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet1_Identification_of_a_DNA_Damage_Response_and_Repair-Related_Gene-Pair_Signature_for_Prognosis_Stratification_Analysis_in_Hepatocellular_Carcinoma_docx/19573999

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curl -L -o "DataSheet1_Identification of a DNA Damage Response and Repair-Related Gene-Pair Signature for Prognosis Stratification Analysis in Hepatocellular Carc.docx" "https://ndownloader.figshare.com/files/34771672"

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• DataSheet1_Identification of a DNA Damage Response and Repair-Related Gene-Pair Signature for Prognosis Stratification Analysis in Hepatocellular Carc.docx（1.92 MB）

文件总体积 1.92 MB（源站 API 实测）。

数据说明

Background: Nowadays, although the cause of hepatocellular carcinoma (HCC) mortality and recurrence remains at a high level, the 5-year survival rate is still very low. The DNA damage response and repair (DDR) pathway may affect HCC patients’ survival by influencing tumor development and therapeutic response. It is necessary to identify a prognostic DDR-related gene signature to predict the outcome of patients.
Methods: Level 3 mRNA expression and clinical information were extracted from the TCGA website. The GSE14520 datasets, ICGC-LIRI datasets, and a Chinese HCC cohort were served as validation sets. Univariate Cox regression analysis and LASSO-penalized Cox regression analysis were performed to construct the DDR-related gene pair (DRGP) signature. Kaplan–Meier survival curves and time-dependent receiver operating characteristic (ROC) analysis curves were calculated to determine the predictive ability of this prognostic model. Then, a prognostic nomogram was established to help clinical management. We investigated the difference in biological processes between HRisk and LRisk by conducting several enrichment analyses. The TIDE algorithm and R package “pRRophetic” were applied to estimate the immunotherapeutic and chemotherapeutic response.
Results: We constructed the prognostic signature based on 23 DDR-related gene pairs. The patients in the training datasets were divided into HRisk and LRisk groups at median cut-off. The HRisk group had significantly poorer OS than the LRisk group, and the signature was an independent prognostic indicator in HCC. Furthermore, a nomogram of the riskscore combined with TNM stage was constructed and detected by the calibration curve and decision curve. The LRisk group was associated with higher expression of HBV oncoproteins and metabolism pathways, while DDR-relevant pathways and cell cycle process were enriched in the HRisk group. Moreover, patients in the LRisk group may be more beneficial from immunotherapy. We also found that TP53 gene was more frequently mutated in the HRisk group. As for chemotherapeutic drugs commonly used in HCC, the HRisk group was highly sensitive to 5-fluorouracil, while the LRisk group presented w

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CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fphar.2022.857060.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet1_Identification_of_a_DNA_Damage_Response_and_Repair-Related_Gene-Pair_Signature_for_Prognosis_Stratification_Analysis_in_Hepatocellular_Carcinoma_docx/19573999）。