患者来源原位模型数据

数据集获取（Figshare）

• 源站标题：Patient-derived orthotopic model data
• DOI：10.6084/m9.figshare.28659197.v1
• 发布日期：2025-08-09
• 文件数：3 个
• 文件总体积：4.78 MB
• 源站页面：https://figshare.com/articles/dataset/Patient-derived_orthotopic_model_data/28659197

命令行下载

curl -L -o "TCGA_mRNA_NodalStatus.tsv" "https://ndownloader.figshare.com/files/53210102"
curl -L -o "tcga.HNSC.maf.RData" "https://ndownloader.figshare.com/files/57057047"
curl -L -o "SomaticPrediction_geneSummary.txt" "https://ndownloader.figshare.com/files/57057062"

文件清单

• TCGA_mRNA_NodalStatus.tsv（1.21 MB）
• tcga.HNSC.maf.RData（3.34 MB）
• SomaticPrediction_geneSummary.txt（230.57 KB）

文件总体积 4.78 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Metastasis presents a significant challenge in head and neck squamous cell carcinoma (HNSC), profoundly impacting patient morbidity and mortality. This proof-of-concept study establishes Patient-Derived Orthotopic Xenografts (PDOXs) as an advanced preclinical model to investigate and address metastatic HNSC. Indeed, PDOX demonstrates noteworthy histopathological and molecular fidelity to primary HNSC tumours. Contrary to the traditional subcutaneous xenografts, PDOXs authentically replicate local lymph node metastasis, mirroring the intricate site-specific cancer–stroma interaction and the disease progression in patients. Furthermore, genomic and transcriptomic analyses underscore the genetic accuracy and heightened resemblance of PDOXs to patient tumours. Notably, NF-κB signalling-induced inflammation emerges as a key driver of the metastatic process, unveiling an inflammatory signature with potential implications as a prognostic marker and therapeutic target. These findings underscore the pivotal role of the PDOX model in capturing the complex biology of HNSC, providing insights for precision-targeted therapies and enhancing patient outcomes.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.28659197.v1（source: https://figshare.com/articles/dataset/Patient-derived_orthotopic_model_data/28659197）。