结肠腺癌TP53突变预后策略数据集

数据集获取（Figshare）

• 源站标题：Datasheet1_A novel strategy for precise prognosis management and treatment option in colon adenocarcinoma with TP53 mutations.pdf
• DOI：10.3389/fsurg.2023.1079129.s001
• 发布日期：2023-02-09
• 文件数：1 个
• 文件总体积：75.23 KB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Datasheet1_A_novel_strategy_for_precise_prognosis_management_and_treatment_option_in_colon_adenocarcinoma_with_TP53_mutations_pdf/22057634

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• Datasheet1_A novel strategy for precise prognosis management and treatment option in colon adenocarcinoma with TP53 mutations.pdf（75.23 KB）

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数据说明

BackgroundTP53 is one of the most frequent mutated genes in colon cancer. Although colon cancer with TP53 mutations has a high risk of metastasis and worse prognosis generally, it showed high heterogeneity clinically.
MethodsA total of 1,412 colon adenocarcinoma (COAD) samples were obtained from two RNA-seq cohorts and three microarray cohorts, including the TCGA-COAD (N = 408), the CPTAC-COAD (N = 106), GSE39582 (N = 541), GSE17536 (N = 171) and GSE41258 (N = 186). The LASSO-Cox method was used to establish the prognostic signature based on the expression data. The patients were divided into high-risk and low-risk groups based on the median risk score. The efficiency of the prognostic signature was validated in various cohorts, including TP53-mutant and TP53 wild-type. The exploration of potential therapeutic targets and agents was performed by using the expression data of TP53-mutant COAD cell lines obtained from the CCLE database and the corresponding drug sensitivity data obtained from the GDSC database.
ResultsA 16-gene prognostic signature was established in TP53-mutant COAD. The high-risk group had significantly inferior survival time compared to the low-risk group in all TP53-mutant datasets, while the prognostic signature failed to classify the prognosis of COAD with TP53 wild-type properly. Besides, the risk score was the independent poor factor for the prognosis in TP53-mutant COAD and the nomogram based on the risk score was also shown good predictive efficiency in TP53-mutant COAD. Moreover, we identified SGPP1, RHOQ, and PDGFRB as potential targets for TP53-mutant COAD, and illuminated that the high-risk patients might benefit from IGFR-3801, Staurosporine, and Sabutoclax.
ConclusionA novel prognostic signature with great efficiency was established especially for COAD patients with TP53 mutations. Besides, we identified novel therapeutic targets and potential sensitive agents for TP53-mutant COAD with high risk. Our findings provided not only a new strategy for prognosis management but also new clues for drug application and precision treatment in COAD with TP53 mutations.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fsurg.2023.1079129.s001（source: https://frontiersin.figshare.com/articles/dataset/Datasheet1_A_novel_strategy_for_precise_prognosis_management_and_treatment_option_in_colon_adenocarcinoma_with_TP53_mutations_pdf/22057634）。