NTRK融合阳性实体肿瘤流行病学系统文献综述
系统文献综述提取的NTRK融合阳性实体肿瘤流行病学数据，涵盖患病率、治疗等指标。
基本信息
资源简介
NTRK融合阳性实体肿瘤流行病学系统文献综述
【一句话概览】
本数据集是 figshare 公开的结构化表格数据集，收录 2 个文件、合计 4.19 MB，主题涵盖 NTRK fusion、solid tumors、TRK inhibitors、prevalence、real-world evidence，可用于统计建模、特征工程与队列分析，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Systematic literature review of the epidemiology of neurotrophic tyrosine receptor kinase positive solid tumor sites》。配套论文《Systematic literature review of the epidemiology of neurotrophic tyrosine receptor kinase positive solid tumor sites》发表于 Future Oncology（2025），DOI：10.1080/14796694.2025.2481022。项目资助方：This manuscript was funded by Bristol Myers Squibb.。源站首次发布：2025-03-28。
【数据内容】
源站原始描述：This study aimed to expand on existing systematic literature reviews (SLRs) by assessing the prevalence of neurotrophic tyrosine receptor kinase (NTRK) fusion-positive mutations across solid tumors in adult U.S populations. It further evaluated incidence, testing, treatment, mortality, and progression rates by tumor type, extending evidence through 2023. A SLR was conducted following Cochrane and PRISMA guidelines, with searches across Ovid Embase, Ovid MEDLINE, and Cochrane Library databases fo…
【数据结构与技术规格】
文件数 2 个，合计 4.19 MB。ifon_a_2481022_sm9736.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，38.09 KB。ifon_a_2481022_sm9732.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，4.15 MB。数据集 DOI：10.6084/m9.figshare.28684119.v1。
【主题与分类】
源站学科分类：Medicine、Pharmacology、Biotechnology、Biological Sciences not elsewhere classified、Cancer。主题标签：NTRK fusion、solid tumors、TRK inhibitors、prevalence、real-world evidence、next-generation sequencing。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://tandf.figshare.com/articles/dataset/Systematic_literature_review_of_the_epidemiology_of_neurotrophic_tyrosine_receptor_kinase_positive_solid_tumor_sites/28684119
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Systematic literature review of the epidemiology of neurotrophic tyrosine receptor kinase positive solid tumor sites. Taylor & Francis. Villacorta, Reginald; Gallagher-Colombo, Shannon; Lahiji, Armin; Myers, Sky; Briggs, Jonathon; Phalguni, Angaja
【使用注意】
· 源站最后修改于 2025-11-13，引用时请注意版本时效。
下载信息
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无需注册即可直接获取公开样本或文档，适合快速预览和评估数据集质量。
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公开数据集受托下载与技术交付服务。
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暂未开放当前数据集主要来源为 Kaggle 公开托管，完整影像包建议通过原始链接或 Kaggle API 获取。
使用方式
数据集获取（Figshare）
- 源站标题：Systematic literature review of the epidemiology of neurotrophic tyrosine receptor kinase positive solid tumor sites
- DOI：10.6084/m9.figshare.28684119.v1
- 发布日期：2025-03-28
- 文件数：2 个
- 文件总体积：4.19 MB
- 源站页面：https://tandf.figshare.com/articles/dataset/Systematic_literature_review_of_the_epidemiology_of_neurotrophic_tyrosine_receptor_kinase_positive_solid_tumor_sites/28684119
命令行下载
curl -L -o "ifon_a_2481022_sm9736.docx" "https://ndownloader.figshare.com/files/53282748"
curl -L -o "ifon_a_2481022_sm9732.docx" "https://ndownloader.figshare.com/files/53282751"
文件清单
ifon_a_2481022_sm9736.docx（38.09 KB）ifon_a_2481022_sm9732.docx（4.15 MB）
文件总体积 4.19 MB（源站 API 实测）。
数据说明
This study aimed to expand on existing systematic literature reviews (SLRs) by assessing the prevalence of neurotrophic tyrosine receptor kinase (NTRK) fusion-positive mutations across solid tumors in adult U.S populations. It further evaluated incidence, testing, treatment, mortality, and progression rates by tumor type, extending evidence through 2023.
A SLR was conducted following Cochrane and PRISMA guidelines, with searches across Ovid Embase, Ovid MEDLINE, and Cochrane Library databases for studies published from 2013 to August 2023. Eligibility criteria included studies on NTRK fusion-positive tumors in patients aged ≥12 years. Data were extracted and assessed using the Newcastle-Ottawa Scale and JBI checklist.
This SLR identified 160 studies, reporting NTRK fusion prevalence ranging from 0.03% to 0.70% across solid tumors. TRK inhibitors, particularly larotrectinib and entrectinib, were commonly used treatments. Prevalence varied significantly by cancer type, being higher in rarer cancers, such as papillary thyroid carcinoma (up to 21.4%).
NTRK fusions are rare, with wide prevalence variability among cancer types. The findings highlight the need for standardized diagnostic methods and larger real-world studies to improve prevalence estimates and assess the impact of NTRK fusions on outcomes, ultimately aiding in the optimization of targeted treatments for affected patients.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.6084/m9.figshare.28684119.v1（source: https://tandf.figshare.com/articles/dataset/Systematic_literature_review_of_the_epidemiology_of_neurotrophic_tyrosine_receptor_kinase_positive_solid_tumor_sites/28684119）。
数据缺失？
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