BreCol
BreCol包含2040个16S rRNA基因测序样本，用于评估微生物组癌症检测方法的跨研究泛化性。
基本信息
资源简介
BreCol
【数据集背景】
本数据集源站标题为《arXiv Query: search_query=&id_list=2609.27207v1&start=0&max_results=1》。源站首次发布：2026-09-23。
【数据内容】
源站原始描述：DNA sequencing of the gut microbial community shows promise for cancer detection, but questions remain about the generalizability of results across studies. We propose BreCol, a benchmark of 2,040 16S rRNA gene sequencing runs across 26 studies spanning breast cancer, colorectal cancer, and healthy cohorts. Train-test splits are made within pre-2023 studies, while holdout evaluation uses studies from 2023 onward, reflecting temporal separation from training data. Classical models reach test/hold…
【主题与分类】
主题标签：q-bio.GN、q-bio.QM。
【适用方向】
组学数据适用于生物标志物发现与分子分型相关建模研究。
【获取与许可】
源站页面：https://arxiv.org/abs/2609.27207v1
下载信息
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使用方式
数据集说明
本数据集 对应论文数据集（arXiv 预印本）。
数据获取指引
- 打开论文页面获取作者与项目信息：https://arxiv.org/abs/2609.27207v1
- 论文 Data Availability / Code Availability 章节标注了数据实际托管位置；
- 获取到实际数据链接后，按对应平台标准方式下载。
论文摘要：Abstract:DNA sequencing of the gut microbial community shows promise for cancer detection, but questions remain about the generalizability of results across studies. We propose BreCol, a benchmark of 2,040 16S rRNA gene sequencing runs across 26 studies spanning breast cancer, colorectal cancer, and healthy cohorts. Train-test splits are made within pre-2023 studies, while holdout evaluation uses studies from 2023 onward, reflecting temporal separation from training data. Classical models reach test/holdout AUCs of 0.77/0.60 for cancer diagnosis and 1.00/0.83 for cancer type prediction. We train the models on both cancer types simultaneously and find that colorectal cancer is often easier to detect than breast cancer. We also evaluate two deep learning models: HyenaDNA, a long-range sequence model that pools hidden states for classification, and SetBERT, a transformer that produces contextualized embeddings over sets of reads. Both deep learning models underperform the best classical methods on holdout data, though tuning training set size and the classification head yields modest gains. Our classical pipeline uses unsupervised clustering to derive features from tetramer frequencies, preserving within-run compositional signal and achieving near state-of-the-art performance without relying on taxonomic assignments. BreCol data and associated code are publicly available.
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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