美国肿瘤学环境中下一代测序使用的障碍与促进因素：一项系统综述

数据集获取（Figshare）

• 源站标题：Barriers and facilitators to next-generation sequencing use in United States oncology settings: a systematic review
• DOI：10.6084/m9.figshare.27096227.v1
• 发布日期：2024-09-24
• 文件数：2 个
• 文件总体积：365.34 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/Barriers_and_facilitators_to_next-generation_sequencing_use_in_United_States_oncology_settings_a_systematic_review/27096227

命令行下载

curl -L -o "NGS SLR supplementary file 1 - protocol.docx" "https://ndownloader.figshare.com/files/49389299"
curl -L -o "NGS SLR supplementary file 2_KM.docx" "https://ndownloader.figshare.com/files/49389302"

文件清单

• NGS SLR supplementary file 1 - protocol.docx（212.82 KB）
• NGS SLR supplementary file 2_KM.docx（152.53 KB）

文件总体积 365.34 KB（源站 API 实测）。

数据说明

Aim: Next-generation sequencing (NGS) of solid tumors can inform treatment decisions; however, uptake remains low. This objective of this systematic review was to identify barriers to and facilitators of NGS in US oncology settings.
Materials & methods: Embase and MEDLINE were searched in March 2023 for articles published from 2012 to 2023 on barriers and facilitators of NGS adoption for solid tumors. Surveys, interviews and observational studies were eligible. Studies on genetic testing for hereditary cancers and non-US studies were excluded. The Motheral scale, Joanna Briggs Institute critical appraisal checklist and McGill Mixed Methods Appraisal Tool were used to assess study quality. Data were synthesized narratively.
Results: Twenty-one studies were included. Study participants were clinicians, payers and administrators. Key barriers included complex reimbursement processes and uncertainties around clinical utility. Including recommendations for NGS in clinical practice guidelines was a key facilitator, although insurance policies were often more restrictive than guideline recommendations.
Conclusion: Uptake of NGS is increasing but barriers remain. Changes to the current reimbursement frameworks are needed to increase access to NGS. The impact of implementing the 2018 National Coverage Determination, which allows access to NGS for all Medicare beneficiaries with advanced cancer, is not yet evident in the published literature.
Next-generation sequencing (NGS) is used in oncology to detect gene mutations such as NTRK, ALK, MET, ROS1 and ALK in solid tumors and thereby inform treatment decisions.
Actionable mutations identified by NGS can be treated with tumor-agnostic targeted therapies, such as larotrectinib and entrectinib.
We conducted a systematic review to investigate the reasons underlying the documented under-use of NGS testing for predictive biomarkers in oncology in the United States.
The 21 studies included in the review represent viewpoints from clinicians, lab personnel, commercial payers and patients with advanced cancer.
Barriers to NGS testing included complex reimbursement processes, uncertainties around clinical utility, lack of sta

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.27096227.v1（source: https://tandf.figshare.com/articles/dataset/Barriers_and_facilitators_to_next-generation_sequencing_use_in_United_States_oncology_settings_a_systematic_review/27096227）。