美国脓毒症住院患者中降钙素原及其他生物标志物的实际使用：一项回顾性观察研究

数据集获取（Figshare）

• 源站标题：Real-world use of procalcitonin and other biomarkers among sepsis hospitalizations in the United States: A retrospective, observational study
• DOI：10.1371/journal.pone.0205924
• 发布日期：2018-10-17
• 文件数：7 个
• 文件总体积：234.00 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Real-world_use_of_procalcitonin_and_other_biomarkers_among_sepsis_hospitalizations_in_the_United_States_A_retrospective_observational_study/7221074

命令行下载

curl -L -o "pone.0205924.s001.docx" "https://ndownloader.figshare.com/files/13296647"
curl -L -o "pone.0205924.s002.docx" "https://ndownloader.figshare.com/files/13296650"
curl -L -o "pone.0205924.s003.docx" "https://ndownloader.figshare.com/files/13296653"
curl -L -o "pone.0205924.s004.docx" "https://ndownloader.figshare.com/files/13296656"
curl -L -o "pone.0205924.s005.docx" "https://ndownloader.figshare.com/files/13296659"
curl -L -o "pone.0205924.s006.docx" "https://ndownloader.figshare.com/files/13296662"
curl -L -o "pone.0205924.s007.pdf" "https://ndownloader.figshare.com/files/13296665"

文件清单

• pone.0205924.s001.docx（20.36 KB）
• pone.0205924.s002.docx（22.48 KB）
• pone.0205924.s003.docx（22.06 KB）
• pone.0205924.s004.docx（21.61 KB）
• pone.0205924.s005.docx（22.81 KB）
• pone.0205924.s006.docx（21.15 KB）
• pone.0205924.s007.pdf（103.53 KB）

文件总体积 234.00 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Sepsis management guidelines endorse use of biomarkers to support clinical assessment and treatment decisions in septic patients. The impact of biomarkers on improving patient outcomes remains uncertain.
Methods
Retrospective observational study of adult sepsis discharges between January 1, 2012, and December 31, 2015, from Premier Healthcare Database hospitals. Sepsis was defined by an All Patients Refined Diagnosis-Related Group code of 720 (septicemia and disseminated infections). Use of four biomarker strategies was evaluated based on hospital records: (i) >1 procalcitonin (PCT), (ii) 1 PCT, (iii) no PCT but ≥1 C-reactive protein (CRP) and/or lactate and (iv) no sepsis biomarkers. Associations between biomarker use and clinical and cost outcomes were examined. The primary outcome was impact of biomarker strategy on hospital costs per day.
Results
Among 933,591 adult sepsis discharges during the study period, 731,392 (78%) had biomarker tests ordered. In multivariable analyses, discharges with >1 PCT had higher hospital costs per day ($1,904; 95% confidence interval [CI] $1,896–$1,911) compared with discharges with no sepsis biomarkers ($1,606; 95% CI $1,658–$1,664). Discharges with >1 PCT also had greater illness severity and antimicrobial exposure compared with other biomarker-use groups. The adjusted odds of dying during hospital stay compared with being discharged were significantly lower for sepsis discharges with >1 PCT (0.64; 95% CI 0.61–0.67) and 1 PCT (0.88; 95% CI 0.85–0.91) compared with no sepsis biomarker use. The proportion of discharges with ≥1 PCT increased almost six-fold during the study; use of other biomarkers remained constant.
Conclusions
Between 2012 and 2015, PCT use among sepsis discharges increased six-fold while lactate and CRP use remained unchanged. PCT use was associated with decreased odds of in-hospital mortality but increased hospital costs per day. Serial biomarker monitoring may be associated with improved patient outcomes in the most critically ill septic patients.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0205924（source: https://plos.figshare.com/articles/dataset/Real-world_use_of_procalcitonin_and_other_biomarkers_among_sepsis_hospitalizations_in_the_United_States_A_retrospective_observational_study/7221074）。