南非早期婴儿HIV诊断计划中确认性检测的价值：一项成本效益分析

数据集获取（Figshare）

• 源站标题：The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis
• DOI：10.1371/journal.pmed.1002446
• 发布日期：2017-11-21
• 文件数：4 个
• 文件总体积：619.02 KB
• 源站页面：https://plos.figshare.com/articles/dataset/The_value_of_confirmatory_testing_in_early_infant_HIV_diagnosis_programmes_in_South_Africa_A_cost-effectiveness_analysis/5621674

命令行下载

curl -L -o "S1 Checklist.docx" "https://ndownloader.figshare.com/files/9791404"
curl -L -o "S1 Table.docx" "https://ndownloader.figshare.com/files/9791419"
curl -L -o "S2 Table.docx" "https://ndownloader.figshare.com/files/9791422"
curl -L -o "S1 Text.docx" "https://ndownloader.figshare.com/files/9791434"

文件清单

• S1 Checklist.docx（135.76 KB）
• S1 Table.docx（165.82 KB）
• S2 Table.docx（95.42 KB）
• S1 Text.docx（222.01 KB）

文件总体积 619.02 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
The specificity of nucleic acid amplification tests (NAATs) used for early infant diagnosis (EID) of HIV infection is Method and findings
Using the Cost-effectiveness of Preventing AIDS Complications (CEPAC)–Pediatric model, we simulated EID testing at age 6 weeks for HIV-exposed infants without and with confirmatory testing. We assumed a NAAT cost of US$25, NAAT specificity of 99.6%, NAAT sensitivity of 100% for infants infected in pregnancy or at least 4 weeks prior to testing, and a mother-to-child transmission (MTCT) rate at 12 months of 4.9%; we simulated guideline-concordant rates of testing uptake, result return, and antiretroviral therapy (ART) initiation (100%). After diagnosis, infants were linked to and retained in care for 10 years (false-positive) or lifelong (true-positive). All parameters were varied widely in sensitivity analyses. Outcomes included number of infants with false-positive diagnoses linked to ART per 1,000 ART initiations, life expectancy (LE, in years) and per-person lifetime HIV-related healthcare costs. Both without and with confirmatory testing, LE was 26.2 years for HIV-infected infants and 61.4 years for all HIV-exposed infants; clinical outcomes for truly infected infants did not differ by strategy. Without confirmatory testing, 128/1,000 ART initiations were false-positive diagnoses; with confirmatory testing, 1/1,000 ART initiations were false-positive diagnoses. Because confirmatory testing averted costly HIV care and ART in truly HIV-uninfected infants, it was cost-saving: total cost US$1,790/infant tested, compared to US$1,830/infant tested without confirmatory testing. Confirmatory testing remained cost-saving unless NAAT cost exceeded US$400 or the HIV-uninfected status of infants incorrectly identified as infected was ascertained and ART stopped within 3 months of starting. Limitations include uncertainty in the data used in the model, which we examined with sensitivity and uncertainty analyses. We also excluded clinical harms to HIV-uninfected infants incorrectly treated with ART after false-positive diagnosis (e.g., medication toxicities); including these outcomes would further increase the value of confir

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1002446（source: https://plos.figshare.com/articles/dataset/The_value_of_confirmatory_testing_in_early_infant_HIV_diagnosis_programmes_in_South_Africa_A_cost-effectiveness_analysis/5621674）。